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> Protein (NX_A1L4K1)
Protein (NX_A1L4K1)
Protein
Gene SymbolFSD2 to neXtProt (NX_A1L4K1)
DescriptionFibronectin type III and SPRY domain-containing protein 2
Chromosome15
Location15q25.2 (83424114 ~ 83474822) to Ensembl
Sequene Features : Isoforms 2, Variants 90, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 90 0
2014-09-19protein level
2 65 0
2014-05-27transcript level
2 65 0
2014-02-25transcript level
1 66 0
2013-12-09transcript level
1 42 0
2013-11-01transcript level
1 42 0
2013-09-12transcript level
1 42 0
2013-08-17transcript level
1 42 0
2013-07-15transcript level
1 23 0
2013-06-11transcript level
1 23 0
2013-02-12transcript level
1 11 0
2012-12-20transcript level
1 6 0
2012-10-30transcript level
1 15 0
2012-10-07transcript level
1 15 0
2012-08-24transcript level
1 12 0
2012-07-28transcript level
1 12 0
2012-06-08transcript level
1 12 0
2012-05-07transcript level
1 12 0
2012-04-10transcript level
1 12 0
2012-01-13transcript level
1 4 0
2011-12-20transcript level
1 4 0
2011-11-11transcript level
1 4 0
2011-08-23transcript level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_A1L4K1-1
4 27 0 85330.9188
NX_A1L4K1-2
1 27 0 80239.5155
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5661036,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
2 EBI-5661036,EBI-1052334 ESD  
  .formaldehyde catabolic process .carboxylic ester hydrolase activity
.methylumbelliferyl-acetate deacetylase activity
.S-formylglutathione hydrolase activity
.hydrolase activity, acting on ester bonds
.extracellular exosome
.cytoplasmic membrane-bounded vesicle
.plasma membrane
  + 3 more...
3 EBI-5661036,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
4 EBI-5661036,EBI-603350 PSMB4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.lipopolysaccharide binding
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
5 EBI-5661036,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
6 EBI-5661036,EBI-1046676 CORO1A  
  .cellular response to interleukin-4
.early endosome to recycling endosome transport
.regulation of release of sequestered calcium ion into cytosol
  + 23 more...
.actin filament binding
.poly(A) RNA binding
.phosphatidylinositol 3-kinase binding
  + 6 more...
.extracellular exosome
.phagocytic vesicle
.protein complex
  + 12 more...
7 EBI-5661036,EBI-741753 NGFRAP1  
  .apoptotic signaling pathway
.neurotrophin TRK receptor signaling pathway
.regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 3 more...
.metal ion binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.cytosol
.cytoplasm
.nucleus
8 EBI-5661036,EBI-10224470 FMR1  
  .mRNA transport
.negative regulation of translational initiation
.negative regulation of translation
.central nervous system development
.poly(A) RNA binding
.mRNA binding
.RNA binding
.neuronal ribonucleoprotein granule
.synapse
.cell body
  + 11 more...
9 EBI-5661036,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-5661036,EBI-396563 PPP2R5D  
  .canonical glycolysis
.stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
  + 20 more...
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.cytosol
.nucleoplasm
.nucleus
.protein phosphatase type 2A complex
11 EBI-5661036,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
12 EBI-5661036,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
13 EBI-5661036,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
14 EBI-5661036,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
15 EBI-5661036,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
16 EBI-5661036,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
17 EBI-5661036,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
18 EBI-5661036,EBI-720304 ZNF410  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-5661036,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
20 EBI-5661036,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
21 EBI-5661036,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
22 EBI-5661036,EBI-745040 CCDC112  
  .N/A .N/A .N/A
23 EBI-5661036,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-5661036,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
25 EBI-5661036,EBI-726510 LENG1  
  .N/A .N/A .N/A
26 EBI-5661036,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
27 EBI-5661036,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-5661036,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
29 EBI-5661036,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
30 EBI-5661036,EBI-10304361 BRD8  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.thyroid hormone receptor activity
.sequence-specific DNA binding transcription factor activity
.NuA4 histone acetyltransferase complex
.mitochondrion
.nucleoplasm
  + 2 more...
31 EBI-5661036,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
32 EBI-5661036,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
33 EBI-5661036,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
34 EBI-5661036,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
35 EBI-5661036,EBI-1105361 ZNF230  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
36 EBI-5661036,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain1
eye9
heart111
intestine4
liver4
lung5
lymph node33
mouth15
muscle37
pancreas4
vascular19
Health State
TissuesTPM*
normal9
leukemia10
Developmental Stage
TissuesTPM*
adult3
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus1.5
heart muscle33.9
prostate1.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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