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> Protein (NX_A5D8V6)
Protein (NX_A5D8V6)
Protein
Gene SymbolVPS37C to neXtProt (NX_A5D8V6)
DescriptionVacuolar protein sorting-associated protein 37C
Chromosome11
Location11q12.2 (60897728 ~ 60929089) to Ensembl
Sequene Features : Isoforms 1, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 49 0
2014-09-19protein level
1 46 0
2014-05-27protein level
1 46 0
2014-02-25protein level
1 46 0
2013-12-09protein level
1 32 0
2013-11-01protein level
1 31 0
2013-09-12protein level
1 31 0
2013-08-17protein level
1 31 0
2013-07-15protein level
1 22 0
2013-06-11protein level
1 22 0
2013-02-12protein level
1 16 0
2012-12-20protein level
1 16 0
2012-10-30protein level
1 15 0
2012-10-07protein level
1 15 0
2012-08-24protein level
1 11 0
2012-07-28protein level
1 11 0
2012-06-08protein level
1 11 0
2012-05-07protein level
1 11 0
2012-04-10protein level
1 11 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_A5D8V6-1
10 0 0 38634.5252
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2559305,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
2 EBI-2559305,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
3 EBI-2559305,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
4 EBI-2559305,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
5 EBI-2559305,EBI-352915 PDCD6  
  .apoptotic signaling pathway
.negative regulation of protein kinase B signaling
.response to calcium ion
  + 12 more...
.binding, bridging
.calcium-dependent protein binding
.protein dimerization activity
  + 4 more...
.endoplasmic reticulum exit site
.extracellular exosome
.nuclear membrane
  + 6 more...
6 EBI-2559305,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
7 EBI-2559305,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
8 EBI-2559305,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
9 EBI-2559305,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
10 EBI-2559305,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
11 EBI-2559305,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-2559305,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-2559305,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
14 EBI-2559305,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
15 EBI-2559305,EBI-946029 C1orf94  
  .N/A .N/A .N/A
16 EBI-2559305,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
17 EBI-2559305,EBI-741424 MAPK1IP1L  
  .N/A .N/A .N/A
18 EBI-2559305,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
19 EBI-2559305,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
20 EBI-2559305,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
21 EBI-2559305,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
22 EBI-2559305,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
23 EBI-2559305,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
24 EBI-2559305,EBI-2554984 TACC3  
  .regulation of cell cycle
.cytoplasmic sequestering of transcription factor
.regulation of microtubule-based process
  + 8 more...
.N/A .centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
blood8
brain18
connective tissue26
ear62
embryonic tissue18
eye57
intestine21
liver14
lung35
mammary gland13
mouth15
ovary9
pancreas56
placenta21
prostate73
skin28
stomach20
testis66
thymus12
uterus30
Health State
TissuesTPM*
normal21
adrenal tumor79
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor17
gastrointestinal tumor16
glioma27
head and neck tumor7
leukemia10
lung tumor29
non-neoplasia10
pancreatic tumor66
primitive neuroectodermal tumor of the CNS39
prostate cancer105
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult27
embryoid body14
blastocyst16
fetus16
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.7
adrenal gland9.4
appendix12.3
bone marrow6.4
cerebral cortex7.7
colon11.4
duodenum16.1
esophagus14.4
gallbladder11.2
heart muscle10.2
kidney9.6
liver3.2
lung12
lymph node8.4
ovary11
pancreas8
placenta13.7
prostate16
salivary gland16.2
skin16.4
small intestine13.5
spleen9
stomach17.4
testis14.1
thyroid gland10.1
urinary bladder10.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasHigh
parathyroid glandLow
placentaMedium
prostateHigh
rectumMedium
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1High
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610038, gene) Vacuolar protein sorting 37, yeast, homolog of, c; VPS37COMIM


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