Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_A5YKK6)
Protein (NX_A5YKK6)
Protein
Gene SymbolCNOT1 to neXtProt (NX_A5YKK6)
DescriptionCCR4-NOT transcription complex subunit 1
Chromosome16
Location16q21 (58553855 ~ 58663790) to Ensembl
Sequene Features : Isoforms 4, Variants 268, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 268 4
2014-09-19protein level
4 195 4
2014-05-27protein level
4 195 4
2014-02-25protein level
4 195 4
2013-12-09protein level
4 173 4
2013-11-01protein level
4 163 2
2013-09-12protein level
4 163 2
2013-08-17protein level
4 163 2
2013-07-15protein level
4 104 2
2013-06-11protein level
4 104 2
2013-02-12protein level
4 41 3
2012-12-20protein level
4 40 3
2012-10-30protein level
4 47 3
2012-10-07protein level
4 47 1
2012-08-24protein level
4 23 1
2012-07-28protein level
4 23 1
2012-06-08protein level
4 32 1
2012-05-07protein level
4 32 1
2012-04-10protein level
4 32 1
2012-01-13protein level
4 10 1
2011-12-20protein level
4 19 1
2011-11-11protein level
4 19 1
2011-08-23protein level
4 19 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_A5YKK6-1
0 119 0 266767.1367
NX_A5YKK6-2
0 118 0 266209.8388
NX_A5YKK6-3
0 106 0 241105.2094
NX_A5YKK6-4
3 73 0 173679.779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1222758,EBI-723281 TOB1  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
2 EBI-1222758,EBI-2269715 TNRC6A  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.micro-ribonucleoprotein complex
.cytosol
.nucleoplasm
.cytoplasmic mRNA processing body
3 EBI-1222758,EBI-1046635 CNOT6L  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.mRNA destabilization
.gene silencing by RNA
  + 8 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.CCR4-NOT complex
.cytosol
.cytoplasm
.nucleus
4 EBI-1222758,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
5 EBI-1222758,EBI-743033 CNOT2  
  .regulation of stem cell maintenance
.RNA phosphodiester bond hydrolysis, exonucleolytic
.negative regulation of intracellular estrogen receptor signaling pathway
  + 10 more...
.RNA polymerase II transcription corepressor binding
.RNA polymerase II transcription cofactor activity
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
6 EBI-1222758,EBI-742299 CNOT8  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
7 EBI-1222758,EBI-2105113 CNOT7  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
8 EBI-1222758,EBI-2562014 CNOT11  
  .gene silencing by RNA
.gene expression
.cell proliferation
  + 5 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
9 EBI-1222758,EBI-2104530 CNOT6  
  .positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
.RNA phosphodiester bond hydrolysis, exonucleolytic
.nuclear-transcribed mRNA catabolic process, no-go decay
  + 10 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.exoribonuclease activity
.RNA binding
.CCR4-NOT complex
.membrane
.cytosol
.nucleus
10 EBI-1222758,EBI-947158 TNRC6B  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.phosphatidylinositol-mediated signaling
  + 10 more...
.poly(A) RNA binding
.nucleotide binding
.cytosol
.cytoplasmic mRNA processing body
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites301
bladder167
blood81
bone209
bone marrow82
brain88
cervix206
connective tissue60
ear124
embryonic tissue267
esophagus49
eye81
heart44
intestine202
kidney151
larynx255
liver126
lung119
lymph225
lymph node345
mammary gland112
mouth241
muscle131
ovary147
pancreas28
parathyroid97
pharynx24
pituitary gland121
placenta14
prostate26
skin80
spleen37
stomach73
testis9
uterus17
vascular38
Health State
TissuesTPM*
normal119
bladder carcinoma170
breast (mammary gland) tumor85
cervical tumor231
chondrosarcoma169
colorectal tumor248
esophageal tumor57
gastrointestinal tumor438
germ cell tumor220
glioma130
head and neck tumor194
kidney tumor130
leukemia116
liver tumor156
lung tumor136
lymphoma152
non-neoplasia72
ovarian tumor196
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
prostate cancer105
retinoblastoma150
skin tumor127
soft tissue/muscle tissue tumor111
uterine tumor88
Developmental Stage
TissuesTPM*
adult154
embryoid body257
blastocyst455
neonate225
fetus118
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.8
adrenal gland36.4
appendix54.7
bone marrow94.5
cerebral cortex23.8
colon62
duodenum62.4
esophagus73.8
gallbladder36.1
heart muscle22.7
kidney41.9
liver26.1
lung42.5
lymph node76.3
ovary40.6
pancreas20.2
placenta39.9
prostate36.3
salivary gland36.6
skin52.3
small intestine49.9
spleen54.3
stomach49
testis109.2
thyroid gland43.3
urinary bladder45.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604917, gene) Ccr4-not transcription complex, subunit 1; CNOT1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center