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> Protein (NX_A7KAX9)
Protein (NX_A7KAX9)
Protein
Gene SymbolARHGAP32 to neXtProt (NX_A7KAX9)
DescriptionRho GTPase-activating protein 32
Chromosome11
Location11q24.3 (128834955 ~ 129149219) to Ensembl
Sequene Features : Isoforms 3, Variants 218, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 218 15
2014-09-19protein level
3 166 15
2014-05-27protein level
3 166 15
2014-02-25protein level
3 163 14
2013-12-09protein level
3 126 14
2013-11-01protein level
3 122 14
2013-09-12protein level
3 122 14
2013-08-17protein level
3 122 14
2013-07-15protein level
3 85 14
2013-06-11protein level
3 85 14
2013-02-12protein level
3 39 18
2012-12-20protein level
3 39 18
2012-10-30protein level
3 46 18
2012-10-07protein level
3 46 9
2012-08-24protein level
3 34 9
2012-07-28protein level
3 34 9
2012-06-08protein level
3 5 9
2012-05-07protein level
3 5 9
2012-04-10protein level
3 5 9
2012-01-13protein level
3 5 9
2011-12-20protein level
3 5 9
2011-11-11protein level
3 5 9
2011-08-23protein level
3 5 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_A7KAX9-1
14 81 2 230384.2728
NX_A7KAX9-2
0 79 2 190850.5517
NX_A7KAX9-3
3 12 1 36645.3674
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-308663,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-308663,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-308663,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
4 EBI-308663,EBI-948630 DZIP3  
  .protein polyubiquitination .poly(A) RNA binding
.polyubiquitin binding
.phosphatase binding
  + 4 more...
.cytoplasm
5 EBI-308663,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
6 EBI-308663,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
7 EBI-308663,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
blood8
bone13
brain75
connective tissue20
ear186
embryonic tissue51
eye100
heart22
intestine146
kidney33
larynx42
liver19
lung26
mammary gland99
mouth151
muscle75
nerve257
ovary19
pancreas51
parathyroid97
pharynx196
placenta35
prostate31
skin33
spleen56
stomach146
testis39
thymus75
trachea96
uterus30
vascular19
Health State
TissuesTPM*
normal56
bladder carcinoma170
breast (mammary gland) tumor96
chondrosarcoma36
colorectal tumor195
gastrointestinal tumor67
germ cell tumor53
glioma46
head and neck tumor134
kidney tumor29
leukemia10
liver tumor10
lung tumor9
non-neoplasia51
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma172
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult63
embryoid body42
blastocyst65
fetus64
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.4
adrenal gland7.6
appendix3.1
bone marrow1.3
cerebral cortex27.7
colon14.8
duodenum19.8
esophagus22.4
gallbladder9.5
heart muscle2.5
kidney7.6
liver2.5
lung5.9
lymph node1.8
ovary11.9
pancreas8
placenta9.5
prostate6.5
salivary gland9.3
skin15.3
small intestine18.3
spleen2.8
stomach11.5
testis13.5
thyroid gland4.7
urinary bladder11
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608541, gene) Rho gtpase involved in beta-catenin, n-cadherin, and nmda receptorOMIM


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