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> Protein (NX_A7MCY6)
Protein (NX_A7MCY6)
Protein
Gene SymbolTBKBP1 to neXtProt (NX_A7MCY6)
DescriptionTANK-binding kinase 1-binding protein 1
Chromosome17
Location17q21.32 (45771447 ~ 45789416) to Ensembl
Sequene Features : Isoforms 2, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 37 9
2014-09-19protein level
2 28 9
2014-05-27protein level
2 28 9
2014-02-25protein level
2 28 9
2013-12-09protein level
2 17 9
2013-11-01protein level
2 17 9
2013-09-12protein level
2 17 9
2013-08-17protein level
2 17 9
2013-07-15protein level
2 11 9
2013-06-11protein level
2 11 9
2013-02-12protein level
2 7 19
2012-12-20protein level
2 7 19
2012-10-30protein level
2 9 19
2012-10-07protein level
2 9 17
2012-08-24protein level
2 9 17
2012-07-28protein level
2 9 17
2012-06-08protein level
2 9 17
2012-05-07protein level
2 8 17
2012-04-10protein level
2 8 17
2012-01-13protein level
2 3 17
2011-12-20protein level
2 3 17
2011-11-11protein level
2 3 17
2011-08-23protein level
2 3 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_A7MCY6-1
21 8 0 67659.633
NX_A7MCY6-2
3 8 0 25027.5436
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359969,EBI-6115839 APBA3  
  .negative regulation of catalytic activity
.protein transport
.regulation of gene expression
  + 2 more...
.enzyme binding
.enzyme inhibitor activity
.beta-amyloid binding
.perinuclear region of cytoplasm
2 EBI-359969,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
3 EBI-359969,EBI-1047793 RB1CC1  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of cell size
.regulation of autophagy
  + 8 more...
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.pre-autophagosomal structure membrane
  + 3 more...
4 EBI-359969,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
5 EBI-359969,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
brain16
connective tissue26
embryonic tissue32
eye38
heart33
intestine8
kidney4
larynx42
lung14
mammary gland6
muscle18
nerve128
pancreas14
placenta3
prostate5
skin18
testis22
thyroid21
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor10
chondrosarcoma12
gastrointestinal tumor16
glioma27
head and neck tumor7
kidney tumor14
leukemia10
non-neoplasia72
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor23
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult12
embryoid body71
blastocyst16
fetus23
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.1
adrenal gland5.8
appendix6.6
bone marrow3.7
cerebral cortex15.1
colon2.8
duodenum1.8
esophagus7.8
gallbladder7.5
heart muscle8.9
kidney7.7
liver1.5
lung6.8
lymph node5
ovary13.4
pancreas3.1
placenta6.4
prostate9.2
salivary gland10
skin3.4
small intestine2.5
spleen11.4
stomach3.7
testis10.3
thyroid gland8
urinary bladder7.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608476, gene) Tbk1-binding protein 1; TBKBP1OMIM


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