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> Protein (NX_O00115)
Protein (NX_O00115)
Protein
Gene SymbolDNASE2 to neXtProt (NX_O00115)
DescriptionDeoxyribonuclease-2-alpha
Chromosome19
Location19p13.2 (12986025 ~ 12992282) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.erythrocyte differentiation
.apoptotic DNA fragmentation
.DNA metabolic process
.deoxyribonuclease II activity
.DNA binding
.extracellular exosome
.lysosome
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 7
2014-09-19protein level
1 25 7
2014-05-27protein level
1 25 7
2014-02-25protein level
1 25 7
2013-12-09protein level
1 21 7
2013-11-01protein level
1 20 7
2013-09-12protein level
1 20 7
2013-08-17protein level
1 20 7
2013-07-15protein level
1 11 7
2013-06-11protein level
1 11 7
2013-02-12protein level
1 7 7
2012-12-20protein level
1 8 7
2012-10-30protein level
1 8 7
2012-10-07protein level
1 8 7
2012-08-24protein level
1 8 7
2012-07-28protein level
1 8 7
2012-06-08protein level
1 22 7
2012-05-07protein level
1 22 7
2012-04-10protein level
1 22 7
2012-01-13protein level
1 20 7
2011-12-20protein level
1 20 7
2011-11-11protein level
1 20 7
2011-08-23protein level
1 20 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00115-1
1 12 0 39555.4349
NX_O00115-2
0 12 0 33593.5933
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051412,EBI-352939 RUVBL2  
  .negative regulation of estrogen receptor binding
.transcriptional activation by promoter-enhancer looping
.cellular response to estradiol stimulus
  + 14 more...
.unfolded protein binding
.ATP-dependent 5'-3' DNA helicase activity
.identical protein binding
  + 7 more...
.MLL1 complex
.extracellular exosome
.NuA4 histone acetyltransferase complex
  + 10 more...
2 EBI-1051412,EBI-353675 RUVBL1  
  .cell division
.histone H2A acetylation
.histone H4 acetylation
  + 11 more...
.ATP binding
.DNA helicase activity
.MLL1 complex
.extracellular exosome
.intracellular membrane-bounded organelle
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland91
ascites125
bladder100
blood32
brain28
cervix185
connective tissue40
embryonic tissue46
eye38
heart55
intestine51
kidney56
liver14
lung32
lymph112
lymph node55
mammary gland72
muscle94
ovary88
pancreas60
pituitary gland121
placenta91
prostate63
salivary gland49
skin23
spleen56
stomach104
testis18
thymus37
thyroid21
umbilical cord145
uterus8
vascular19
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor85
cervical tumor202
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor143
germ cell tumor37
glioma65
head and neck tumor14
kidney tumor72
liver tumor10
lung tumor9
lymphoma83
non-neoplasia72
ovarian tumor78
pancreatic tumor104
primitive neuroectodermal tumor of the CNS125
prostate cancer86
retinoblastoma107
skin tumor23
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult42
embryoid body28
blastocyst81
neonate128
fetus16
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.8
adrenal gland19.8
appendix23.1
bone marrow5.6
cerebral cortex16.6
colon20.9
duodenum17.3
esophagus16.3
gallbladder30.1
heart muscle18
kidney16.9
liver22.1
lung36.7
lymph node44.5
ovary26.1
pancreas17.4
placenta20.5
prostate25.9
salivary gland23.8
skin21.5
small intestine13.2
spleen20.8
stomach25.8
testis7.7
thyroid gland46.2
urinary bladder33
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastLow
bronchusLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
oral mucosaLow
placentaLow
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
small intestineMedium
stomach 1Medium
testisLow
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*126350, gene) Deoxyribonuclease ii, lysosomal; DNASE2OMIM


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