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> Protein (NX_O00142)
Protein (NX_O00142)
Protein
Gene SymbolTK2 to neXtProt (NX_O00142)
DescriptionThymidine kinase 2, mitochondrial
Chromosome16
Location16q21 (66541906 ~ 66586447) to Ensembl
Sequene Features : Isoforms 5, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA biosynthetic process
.nucleobase-containing small molecule metabolic process
.thymidine metabolic process
  + 7 more...
.ATP binding
.thymidine kinase activity
.deoxycytidine kinase activity
.mitochondrial matrix
.mitochondrial inner membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 33 0
2014-09-19protein level
5 28 0
2014-05-27protein level
5 27 0
2014-02-25protein level
4 27 0
2013-12-09protein level
4 22 0
2013-11-01protein level
4 22 0
2013-09-12protein level
4 22 0
2013-08-17protein level
4 22 0
2013-07-15protein level
4 15 0
2013-06-11protein level
4 15 0
2013-02-12protein level
4 13 0
2012-12-20protein level
4 14 0
2012-10-30protein level
3 14 0
2012-10-07protein level
3 14 0
2012-08-24protein level
3 13 0
2012-07-28protein level
3 13 0
2012-06-08protein level
3 17 0
2012-05-07protein level
3 17 0
2012-04-10protein level
2 17 0
2012-01-13protein level
2 12 0
2011-12-20protein level
2 12 0
2011-11-11protein level
2 12 0
2011-08-23protein level
2 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00142-1
0 13 0 30984.7488
NX_O00142-2
1 12 0 27543.8048
NX_O00142-3
1 11 0 28355.5518
NX_O00142-4
1 11 0 28901.6112
NX_O00142-5
0 9 0 20268.2252
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood8
bone69
brain53
cervix123
connective tissue33
ear62
embryonic tissue9
eye14
heart44
intestine8
kidney33
larynx42
liver4
lung35
lymph node11
mammary gland6
mouth30
muscle37
nerve193
pancreas14
pharynx24
pituitary gland60
placenta24
prostate26
skin14
stomach10
testis75
thymus25
thyroid42
uterus12
Health State
TissuesTPM*
normal35
adrenal tumor79
cervical tumor57
chondrosarcoma84
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
head and neck tumor37
kidney tumor29
liver tumor10
lung tumor19
non-neoplasia20
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
embryoid body14
blastocyst16
fetus93
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.6
adrenal gland24.7
appendix10.7
bone marrow5.4
cerebral cortex18.7
colon12.4
duodenum10.1
esophagus13.2
gallbladder23.7
heart muscle14.2
kidney20.2
liver15
lung19.2
lymph node12.7
ovary26.1
pancreas10.8
placenta13.5
prostate15.7
salivary gland16
skin9.5
small intestine12
spleen20.8
stomach11.6
testis31.7
thyroid gland29.5
urinary bladder20.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*188250, gene) Thymidine kinase, mitochondrial; TK2OMIM
2(#609560, phenotype) Mitochondrial dna depletion syndrome 2 (myopathic type); MTDPS2OMIM


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