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> Protein (NX_O00189)
Protein (NX_O00189)
Protein
Gene SymbolAP4M1 to neXtProt (NX_O00189)
DescriptionAP-4 complex subunit mu-1
Chromosome7
Location7q22.1 (99699172 ~ 99707968) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.vesicle-mediated transport
.Golgi to endosome transport
  + 2 more...
.transporter activity .extracellular exosome
.trans-Golgi network membrane
.endosome lumen
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 2
2014-09-19protein level
1 44 2
2014-05-27protein level
1 44 2
2014-02-25protein level
1 44 2
2013-12-09protein level
1 32 2
2013-11-01protein level
1 32 1
2013-09-12protein level
1 32 1
2013-08-17protein level
1 32 1
2013-07-15protein level
1 22 0
2013-06-11protein level
1 22 0
2013-02-12protein level
1 10 1
2012-12-20protein level
1 10 1
2012-10-30protein level
1 11 1
2012-10-07protein level
1 11 1
2012-08-24protein level
1 11 1
2012-07-28protein level
1 11 1
2012-06-08protein level
1 16 1
2012-05-07protein level
1 13 1
2012-04-10protein level
1 13 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00189-1
23 0 0 49945.7478
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3914106,EBI-2514143 USP47  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.regulation of proteasomal protein catabolic process
.negative regulation of transcription, DNA-templated
  + 10 more...
.WD40-repeat domain binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.SCF ubiquitin ligase complex
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood32
bone41
brain55
cervix41
connective tissue20
ear62
embryonic tissue32
eye19
heart44
intestine47
kidney9
liver48
lung29
mammary gland52
mouth15
muscle28
ovary39
pancreas51
placenta31
prostate36
salivary gland49
spleen56
stomach31
testis91
thymus25
tonsil117
trachea38
uterus47
vascular19
Health State
TissuesTPM*
normal40
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor25
germ cell tumor22
glioma27
head and neck tumor14
leukemia21
liver tumor62
lung tumor38
lymphoma55
non-neoplasia20
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS62
prostate cancer48
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult32
embryoid body14
blastocyst48
fetus43
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland11.5
appendix8.4
bone marrow5.3
cerebral cortex10.1
colon11.9
duodenum12.8
esophagus11.4
gallbladder12.1
heart muscle9.7
kidney11.8
liver3.3
lung14.8
lymph node8.2
ovary12.1
pancreas6.5
placenta9
prostate12.9
salivary gland8.9
skin12.8
small intestine13.8
spleen8.3
stomach12.8
testis28.9
thyroid gland11
urinary bladder11
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602296, gene) Adaptor-related protein complex 4, mu-1 subunit; AP4M1OMIM
2(#612936, phenotype) Spastic paraplegia 50, autosomal recessive; SPG50OMIM


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