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> Protein (NX_O00198)
Protein (NX_O00198)
Protein
Gene SymbolHRK to neXtProt (NX_O00198)
DescriptionActivator of apoptosis harakiri
Chromosome12
Location12q24.22 (117293949 ~ 117319246) to Ensembl
Sequene Features : Isoforms 1, Variants 2, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of release of cytochrome c from mitochondria
.positive regulation of apoptotic process
.positive regulation of protein homooligomerization
.apoptotic process
.N/A .integral component of membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 2 0
2014-09-19protein level
1 2 0
2014-05-27protein level
1 2 0
2014-02-25protein level
1 2 0
2013-12-09protein level
1 1 0
2013-11-01protein level
1 1 0
2013-09-12protein level
1 1 0
2013-08-17protein level
1 1 0
2013-07-15protein level
1 1 0
2013-06-11protein level
1 1 0
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 0 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00198-1
5 0 0 9877.1831
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-701322,EBI-347528 C1QBP  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of trophoblast cell migration
.positive regulation of substrate adhesion-dependent cell spreading
  + 25 more...
.mitochondrial ribosome binding
.adrenergic receptor binding
.kininogen binding
  + 5 more...
.membrane
.cell surface
.plasma membrane
  + 7 more...
2 EBI-701322,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
lymph node11
placenta3
testis2
thyroid21
Health State
TissuesTPM*
normal1
germ cell tumor3
head and neck tumor7
leukemia31
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult2
fetus3
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex8.5
thyroid gland4.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603447, gene) Harakiri; HRKOMIM


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