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> Protein (NX_O00214)
Protein (NX_O00214)
Protein
Gene SymbolLGALS8 to neXtProt (NX_O00214)
DescriptionGalectin-8
Chromosome1
Location1q43 (236681300 ~ 236716281) to Ensembl
Sequene Features : Isoforms 2, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.T cell costimulation
.plasma cell differentiation
.carbohydrate binding .extracellular exosome
.membrane
.cytoplasm
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 50 2
2014-09-19protein level
2 42 2
2014-05-27protein level
2 42 2
2014-02-25protein level
2 41 2
2013-12-09protein level
2 32 2
2013-11-01protein level
2 30 0
2013-09-12protein level
2 30 0
2013-08-17protein level
2 30 0
2013-07-15protein level
2 22 0
2013-06-11protein level
2 22 0
2013-02-12protein level
2 13 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 13 0
2012-10-07protein level
2 13 0
2012-08-24protein level
2 12 0
2012-07-28protein level
2 13 0
2012-06-08protein level
2 22 0
2012-05-07protein level
2 19 0
2012-04-10protein level
2 19 0
2012-01-13protein level
2 17 0
2011-12-20protein level
2 17 0
2011-11-11protein level
2 17 0
2011-08-23protein level
2 17 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00214-1
0 19 0 35785.4401
NX_O00214-2
3 19 0 40371.8005
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740058,EBI-723792 APEH  
  .beta-amyloid metabolic process
.proteolysis
.poly(A) RNA binding
.omega peptidase activity
.serine-type endopeptidase activity
.extracellular exosome
.nuclear membrane
.cytoplasm
2 EBI-740058,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
3 EBI-740058,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
4 EBI-740058,EBI-714215 TGIF1  
  .retina development in camera-type eye
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of fibroblast proliferation
  + 14 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.nucleoplasm
5 EBI-740058,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
6 EBI-740058,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites175
bladder33
blood32
bone41
bone marrow41
brain6
cervix82
connective tissue33
ear124
embryonic tissue65
esophagus99
eye38
heart55
intestine38
kidney4
larynx213
liver4
lung2
lymph22
lymph node133
mammary gland59
mouth15
muscle37
nerve128
ovary39
pancreas37
parathyroid97
pharynx73
pituitary gland60
placenta7
prostate26
salivary gland49
skin4
spleen37
stomach20
testis13
thymus12
thyroid64
trachea96
umbilical cord145
uterus47
vascular58
Health State
TissuesTPM*
normal6
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor75
cervical tumor115
chondrosarcoma60
colorectal tumor53
esophageal tumor115
gastrointestinal tumor75
germ cell tumor94
glioma9
head and neck tumor7
kidney tumor14
leukemia31
liver tumor83
lung tumor58
lymphoma13
non-neoplasia51
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer28
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult1
embryoid body14
blastocyst97
neonate160
fetus8
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.7
adrenal gland22.3
appendix44.9
bone marrow52
cerebral cortex21.6
colon25.8
duodenum37.5
esophagus30.8
gallbladder39.7
heart muscle47.2
kidney26.9
liver30.4
lung36.9
lymph node38.8
ovary36
pancreas19.1
placenta49.6
prostate31.1
salivary gland20.4
skin55.5
small intestine32.9
spleen62.6
stomach33.1
testis60
thyroid gland25.9
urinary bladder44
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 2Medium
small intestineMedium
soft tissue 1Low
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606099, gene) Lectin, galactoside-binding, soluble, 8; LGALS8OMIM


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