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> Protein (NX_O00222)
Protein (NX_O00222)
Protein
Gene SymbolGRM8 to neXtProt (NX_O00222)
DescriptionMetabotropic glutamate receptor 8
Chromosome7
Location7q31.33 (126078652 ~ 126893348) to Ensembl
Sequene Features : Isoforms 3, Variants 291, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of synaptic transmission, glutamatergic
.negative regulation of cAMP biosynthetic process
.sensory perception of smell
  + 2 more...
.glutamate receptor activity
.G-protein coupled receptor activity
.group III metabotropic glutamate receptor activity
.presynaptic membrane
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
3 291 14
2014-09-19transcript level
3 209 14
2014-05-27transcript level
3 205 14
2014-02-25transcript level
3 203 14
2013-12-09transcript level
3 183 14
2013-11-01transcript level
3 174 14
2013-09-12transcript level
3 174 14
2013-08-17transcript level
3 174 14
2013-07-15transcript level
3 135 14
2013-06-11transcript level
3 135 14
2013-02-12transcript level
3 65 34
2012-12-20transcript level
3 64 34
2012-10-30transcript level
3 71 34
2012-10-07transcript level
3 71 14
2012-08-24transcript level
3 29 14
2012-07-28transcript level
3 29 14
2012-06-08transcript level
3 34 14
2012-05-07transcript level
3 34 14
2012-04-10transcript level
3 34 14
2012-01-13transcript level
3 24 14
2011-12-20transcript level
3 24 14
2011-11-11transcript level
3 24 14
2011-08-23transcript level
3 24 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00222-1
2 41 1 101674.5532
NX_O00222-2
2 41 1 101542.5034
NX_O00222-3
3 23 0 55912.3077
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain11
connective tissue570
intestine17
kidney4
lung29
mammary gland6
mouth15
testis11
Health State
TissuesTPM*
normal6
colorectal tumor35
germ cell tumor7
head and neck tumor7
soft tissue/muscle tissue tumor678
Developmental Stage
TissuesTPM*
adult48
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.6
cerebral cortex4.6
colon3.2
kidney1
liver2.3
ovary1.7
testis6
thyroid gland1.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601116, gene) Glutamate receptor, metabotropic, 8; GRM8OMIM


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