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> Protein (NX_O00238)
Protein (NX_O00238)
Protein
Gene SymbolBMPR1B to neXtProt (NX_O00238)
DescriptionBone morphogenetic protein receptor type-1B
Chromosome4
Location4q22.3 (95679119 ~ 96079599) to Ensembl
Sequene Features : Isoforms 2, Variants 84, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of chondrocyte proliferation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of cartilage development
  + 18 more...
.metal ion binding
.SMAD binding
.ATP binding
  + 4 more...
.receptor complex
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 84 6
2014-09-19protein level
2 71 6
2014-05-27protein level
2 71 6
2014-02-25protein level
2 70 6
2013-12-09protein level
2 54 6
2013-11-01protein level
2 50 6
2013-09-12protein level
2 50 6
2013-08-17protein level
2 50 6
2013-07-15protein level
2 39 5
2013-06-11protein level
2 39 5
2013-02-12protein level
2 21 10
2012-12-20protein level
1 21 5
2012-10-30protein level
1 27 5
2012-10-07protein level
1 27 5
2012-08-24protein level
1 27 5
2012-07-28protein level
1 27 5
2012-06-08protein level
1 27 5
2012-05-07protein level
1 18 5
2012-04-10protein level
1 18 5
2012-01-13protein level
1 10 5
2011-12-20protein level
1 10 5
2011-11-11protein level
1 10 5
2011-08-23protein level
1 10 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00238-1
0 20 4 56893.4871
NX_O00238-2
2 20 4 60542.3507
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7527193,EBI-1029262 BMP2  
  .negative regulation of cardiac muscle cell differentiation
.negative regulation of cortisol biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
  + 81 more...
.BMP receptor binding
.protein heterodimerization activity
.SMAD binding
  + 5 more...
.cell surface
.extracellular space
.extracellular region
2 EBI-7527193,EBI-8571476 GDF5  
  .negative regulation of mesenchymal cell apoptotic process
.activation of mitophagy in response to mitochondrial depolarization
.chondroblast differentiation
  + 22 more...
.identical protein binding
.BMP binding
.growth factor activity
  + 2 more...
.plasma membrane
.extracellular space
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain8
connective tissue6
embryonic tissue9
eye19
kidney14
liver4
lung23
mammary gland26
muscle9
nerve128
ovary98
pancreas9
prostate58
testis4
trachea57
uterus4
vascular38
Health State
TissuesTPM*
normal8
breast (mammary gland) tumor32
chondrosarcoma12
germ cell tumor7
liver tumor10
ovarian tumor131
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer57
retinoblastoma43
Developmental Stage
TissuesTPM*
adult19
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland5
cerebral cortex11.6
gallbladder3.5
kidney6.8
lung1.8
ovary6.8
prostate26.5
spleen1
stomach1.6
testis4.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#112600, phenotype) Brachydactyly, type a2; BDA2OMIM
2(*603248, gene) Bone morphogenetic protein receptor, type ib; BMPR1BOMIM
3(#609441, phenotype) Chondrodysplasia, acromesomelic, with genital anomaliesOMIM


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