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> Protein (NX_O00241)
Protein (NX_O00241)
Protein
Gene SymbolSIRPB1 to neXtProt (NX_O00241)
DescriptionSignal-regulatory protein beta-1
Chromosome20
Location20p13 (1544167 ~ 1600707) to Ensembl
Sequene Features : Isoforms 2, Variants 117, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.cell surface receptor signaling pathway
.signal transduction
.N/A .extracellular exosome
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 117 6
2014-09-19protein level
2 92 6
2014-05-27protein level
2 92 7
2014-02-25protein level
2 91 7
2013-12-09protein level
2 74 7
2013-11-01protein level
2 68 6
2013-09-12protein level
2 68 6
2013-08-17protein level
2 68 6
2013-07-15protein level
2 51 6
2013-06-11protein level
2 51 6
2013-02-12protein level
2 35 7
2012-12-20protein level
2 35 7
2012-10-30protein level
2 42 7
2012-10-07protein level
2 42 7
2012-08-24protein level
2 37 7
2012-07-28protein level
2 37 7
2012-06-08protein level
2 39 7
2012-05-07protein level
2 39 7
2012-04-10protein level
2 39 7
2012-01-13protein level
2 18 7
2011-12-20protein level
2 18 7
2011-11-11protein level
2 18 7
2011-08-23protein level
2 18 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00241-1
11 6 5 43183.834
NX_O00241-2
1 6 3 19381.212
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2615458,EBI-2214794 TYROBP  
  .regulation of osteoclast development
.regulation of immune response
.innate immune response
  + 7 more...
.identical protein binding
.receptor binding
.receptor signaling protein activity
.cell surface
.integral component of plasma membrane
.plasma membrane
2 EBI-10179231,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
3 EBI-10179231,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood220
bone marrow123
brain17
connective tissue6
eye4
intestine4
lung26
mammary gland6
mouth15
pharynx24
prostate5
skin9
spleen131
stomach10
thyroid64
uterus8
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
head and neck tumor22
leukemia179
skin tumor15
Developmental Stage
TissuesTPM*
adult19
neonate32
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland7.1
appendix33.6
bone marrow33
cerebral cortex19.3
colon3.6
duodenum5
esophagus3.2
gallbladder16.6
heart muscle3.8
kidney3.9
liver3.9
lung17.3
lymph node12.1
ovary2.9
pancreas1.1
placenta6.6
prostate1.7
salivary gland4
skin3.8
small intestine5
spleen14.4
stomach2.8
testis1.9
thyroid gland1.5
urinary bladder11.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603889, gene) Signal regulatory protein, beta-1; SIRPB1OMIM


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