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> Protein (NX_O00257)
Protein (NX_O00257)
Protein
Gene SymbolCBX4 to neXtProt (NX_O00257)
DescriptionE3 SUMO-protein ligase CBX4
Chromosome17
Location17q25.3 (77806955 ~ 77813228) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 7
2014-09-19protein level
2 36 8
2014-05-27protein level
2 36 8
2014-02-25protein level
2 35 8
2013-12-09protein level
2 26 7
2013-11-01protein level
2 25 7
2013-09-12protein level
2 25 7
2013-08-17protein level
2 25 7
2013-07-15protein level
2 21 7
2013-06-11protein level
2 21 7
2013-02-12protein level
2 9 10
2012-12-20protein level
2 9 10
2012-10-30protein level
2 9 10
2012-10-07protein level
2 9 6
2012-08-24protein level
2 6 6
2012-07-28protein level
2 6 6
2012-06-08protein level
2 12 6
2012-05-07protein level
2 11 6
2012-04-10protein level
2 11 6
2012-01-13protein level
2 12 6
2011-12-20protein level
2 12 6
2011-11-11protein level
2 12 5
2011-08-23protein level
2 12 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00257-1
15 11 0 61329.2888
NX_O00257-3
1 11 0 31967.5261
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722425,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
2 EBI-722425,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
3 EBI-4392727,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
4 EBI-4392727,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
5 EBI-4392727,EBI-348169 CSNK2B  
  .endothelial tube morphogenesis
.regulation of DNA binding
.regulation of protein kinase activity
  + 11 more...
.metal ion binding
.identical protein binding
.protein domain specific binding
  + 4 more...
.extracellular exosome
.protein kinase CK2 complex
.cytosol
  + 2 more...
6 EBI-4392727,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
7 EBI-722425,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
8 EBI-4392727,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
9 EBI-4392727,EBI-1048026 PCGF6  
  .negative regulation of transcription, DNA-templated .zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 2 more...
.PRC1 complex
.PcG protein complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain6
cervix82
connective tissue6
embryonic tissue9
eye4
intestine30
kidney4
larynx85
liver9
lung8
lymph45
lymph node11
mammary gland19
ovary9
pancreas9
placenta3
prostate10
skin23
stomach10
thymus37
uterus12
vascular19
Health State
TissuesTPM*
normal7
breast (mammary gland) tumor32
cervical tumor86
colorectal tumor17
gastrointestinal tumor33
germ cell tumor3
glioma46
head and neck tumor14
leukemia10
liver tumor10
lymphoma41
ovarian tumor13
pancreatic tumor19
prostate cancer19
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult11
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland5.3
appendix9.9
bone marrow63.5
cerebral cortex10.7
colon4.3
duodenum4
esophagus5.5
gallbladder5.4
heart muscle4.5
kidney6.1
liver4.7
lung7.9
lymph node10.8
ovary5.4
pancreas6.4
placenta13.2
prostate7.4
salivary gland6.4
skin5.9
small intestine4.7
spleen14.7
stomach8.3
testis4.7
thyroid gland6.7
urinary bladder7.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603079, gene) Chromobox homolog 4, drosophila polycomb class; CBX4OMIM


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