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> Protein (NX_O00267)
Protein (NX_O00267)
Protein
Gene SymbolSUPT5H to neXtProt (NX_O00267)
DescriptionTranscription elongation factor SPT5
Chromosome19
Location19q13.2 (39926796 ~ 39967310) to Ensembl
Sequene Features : Isoforms 2, Variants 115, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.protein heterodimerization activity
.poly(A) RNA binding
.enzyme binding
.chromatin binding
.DSIF complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 115 22
2014-09-19protein level
2 86 22
2014-05-27protein level
2 86 22
2014-02-25protein level
2 85 21
2013-12-09protein level
2 79 21
2013-11-01protein level
2 71 17
2013-09-12protein level
2 71 18
2013-08-17protein level
2 71 18
2013-07-15protein level
2 45 16
2013-06-11protein level
2 45 16
2013-02-12protein level
2 14 38
2012-12-20protein level
2 15 36
2012-10-30protein level
2 19 36
2012-10-07protein level
2 19 18
2012-08-24protein level
2 16 18
2012-07-28protein level
2 16 18
2012-06-08protein level
2 28 18
2012-05-07protein level
2 18 18
2012-04-10protein level
2 18 18
2012-01-13protein level
2 16 18
2011-12-20protein level
2 16 18
2011-11-11protein level
2 16 17
2011-08-23protein level
2 16 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00267-1
1 47 0 120924.1729
NX_O00267-2
1 47 0 120423.9623
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-710464,EBI-295301 POLR2A  
  .positive regulation of viral transcription
.somatic stem cell maintenance
.piRNA metabolic process
  + 13 more...
.metal ion binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
  + 3 more...
.DNA-directed RNA polymerase II, core complex
.nucleoplasm
.nucleus
2 EBI-710464,EBI-437708 PPIA  
  .establishment of integrated proviral latency
.leukocyte migration
.positive regulation of protein secretion
  + 15 more...
.unfolded protein binding
.virion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.focal adhesion
  + 4 more...
3 EBI-710464,EBI-727250 SUPT4H1  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription elongation from RNA polymerase II promoter
  + 10 more...
.protein heterodimerization activity
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DSIF complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder100
blood49
bone marrow20
brain278
cervix144
connective tissue114
embryonic tissue150
esophagus49
eye129
heart22
intestine73
kidney85
larynx170
liver77
lung128
lymph112
lymph node133
mammary gland99
mouth196
muscle235
nerve128
ovary167
pancreas290
pharynx73
placenta166
prostate116
salivary gland98
skin85
spleen93
stomach31
testis301
thymus213
thyroid171
tonsil176
trachea366
umbilical cord363
uterus155
vascular58
Health State
TissuesTPM*
normal164
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor144
chondrosarcoma156
colorectal tumor88
esophageal tumor57
gastrointestinal tumor84
germ cell tumor125
glioma130
head and neck tumor171
kidney tumor130
leukemia21
liver tumor114
lung tumor136
lymphoma96
non-neoplasia113
ovarian tumor210
pancreatic tumor447
primitive neuroectodermal tumor of the CNS94
prostate cancer173
retinoblastoma258
skin tumor103
soft tissue/muscle tissue tumor135
uterine tumor133
Developmental Stage
TissuesTPM*
adult125
embryoid body171
blastocyst292
neonate128
fetus141
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.5
adrenal gland47.2
appendix54
bone marrow70
cerebral cortex48
colon39.1
duodenum46.9
esophagus31.5
gallbladder45.7
heart muscle39.3
kidney40.2
liver31.6
lung45.9
lymph node58
ovary54.3
pancreas27.3
placenta44.3
prostate47.4
salivary gland43.6
skin49.5
small intestine43.2
spleen57.8
stomach46.9
testis111.7
thyroid gland54.5
urinary bladder40.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602102, gene) Suppressor of ty 5, s. cerevisiae, homolog of; SUPT5HOMIM


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