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> Protein (NX_O00291)
Protein (NX_O00291)
Protein
Gene SymbolHIP1 to neXtProt (NX_O00291)
DescriptionHuntingtin-interacting protein 1
Chromosome7
Location7q11.23 (75162621 ~ 75368280) to Ensembl
Sequene Features : Isoforms 2, Variants 122, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.clathrin-mediated endocytosis
.clathrin coat assembly
  + 7 more...
.phosphatidylinositol binding
.clathrin binding
.structural constituent of cytoskeleton
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
.clathrin-coated vesicle
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 122 4
2014-09-19protein level
2 96 4
2014-05-27protein level
2 95 4
2014-02-25protein level
2 96 4
2013-12-09protein level
2 77 4
2013-11-01protein level
2 74 2
2013-09-12protein level
2 74 3
2013-08-17protein level
2 74 3
2013-07-15protein level
2 55 3
2013-06-11protein level
2 55 3
2013-02-12protein level
2 28 6
2012-12-20protein level
2 28 6
2012-10-30protein level
1 31 3
2012-10-07protein level
1 31 3
2012-08-24protein level
1 19 3
2012-07-28protein level
1 19 3
2012-06-08protein level
1 27 3
2012-05-07protein level
1 27 3
2012-04-10protein level
1 27 3
2012-01-13protein level
1 17 3
2011-12-20protein level
1 17 3
2011-11-11protein level
1 17 1
2011-08-23protein level
1 17 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00291-1
1 46 2 116148.1613
NX_O00291-3
1 46 2 110593.2681
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473886,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-473886,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-473886,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bone27
bone marrow20
brain37
cervix20
connective tissue26
embryonic tissue98
eye33
heart44
intestine8
kidney37
liver14
lung41
lymph node22
mammary gland33
mouth30
muscle37
nerve64
ovary98
pancreas28
placenta45
prostate10
skin80
stomach52
testis103
thyroid42
tonsil58
trachea19
umbilical cord72
uterus38
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma24
gastrointestinal tumor42
germ cell tumor37
glioma55
head and neck tumor29
kidney tumor58
leukemia10
liver tumor20
lung tumor29
non-neoplasia31
ovarian tumor118
pancreatic tumor57
retinoblastoma64
skin tumor127
soft tissue/muscle tissue tumor119
uterine tumor66
Developmental Stage
TissuesTPM*
adult39
embryoid body85
blastocyst48
neonate32
fetus48
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.7
adrenal gland8.3
appendix7.2
bone marrow4.8
cerebral cortex18.2
colon4.4
duodenum2.8
esophagus5.2
gallbladder9.6
heart muscle7.4
kidney13.5
liver4.5
lung19.8
lymph node4.8
ovary6.9
pancreas1.8
placenta15
prostate6.5
salivary gland1.6
skin9.8
small intestine3.1
spleen12
stomach4.2
testis31.1
thyroid gland16.3
urinary bladder10.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusLow
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601767, gene) Huntingtin-interacting protein 1; HIP1OMIM
2chronic myelomonocytic leukemiaCGP


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