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> Protein (NX_O00294)
Protein (NX_O00294)
Protein
Gene SymbolTULP1 to neXtProt (NX_O00294)
DescriptionTubby-related protein 1
Chromosome6
Location6p21.31 (35465651 ~ 35480715) to Ensembl
Sequene Features : Isoforms 2, Variants 113, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.retina development in camera-type eye
.detection of light stimulus involved in visual perception
.positive regulation of phagocytosis
  + 7 more...
.actin filament binding
.G-protein coupled photoreceptor activity
.phosphatidylinositol-4,5-bisphosphate binding
.synapse
.cell projection
.cell junction
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 113 0
2014-09-19protein level
2 81 0
2014-05-27protein level
2 81 0
2014-02-25protein level
2 81 0
2013-12-09protein level
2 66 0
2013-11-01protein level
2 63 0
2013-09-12protein level
2 63 0
2013-08-17protein level
2 63 0
2013-07-15protein level
2 49 0
2013-06-11protein level
2 49 0
2013-02-12protein level
2 39 0
2012-12-20protein level
2 39 0
2012-10-30protein level
2 42 0
2012-10-07protein level
2 42 0
2012-08-24protein level
2 36 0
2012-07-28protein level
2 36 0
2012-06-08protein level
2 36 0
2012-05-07protein level
2 36 0
2012-04-10protein level
2 36 0
2012-01-13protein level
2 27 0
2011-12-20protein level
2 27 0
2011-11-11protein level
2 27 0
2011-08-23protein level
2 24 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00294-1
3 22 0 60572.2684
NX_O00294-2
1 22 0 54633.242
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1756778,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain3
embryonic tissue14
eye177
intestine4
lung2
muscle9
placenta7
Health State
TissuesTPM*
normal10
leukemia10
retinoblastoma323
Developmental Stage
TissuesTPM*
adult13
embryoid body14
blastocyst32
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
prostate1.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#600132, phenotype) Retinitis pigmentosa 14; RP14OMIM
2(*602280, gene) Tubby-like protein 1; TULP1OMIM
3(#613843, phenotype) Leber congenital amaurosis 15; LCA15OMIM


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