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> Protein (NX_O00308)
Protein (NX_O00308)
Protein
Gene SymbolWWP2 to neXtProt (NX_O00308)
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP2
Chromosome16
Location16q22.1 (69796209 ~ 69975644) to Ensembl
Sequene Features : Isoforms 4, Variants 125, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 125 2
2014-09-19protein level
4 91 2
2014-05-27protein level
4 91 2
2014-02-25protein level
3 91 2
2013-12-09protein level
3 72 2
2013-11-01protein level
3 68 1
2013-09-12protein level
3 68 1
2013-08-17protein level
3 68 1
2013-07-15protein level
3 49 1
2013-06-11protein level
3 49 1
2013-02-12protein level
2 29 2
2012-12-20protein level
2 27 2
2012-10-30protein level
1 34 1
2012-10-07protein level
1 34 1
2012-08-24protein level
1 30 1
2012-07-28protein level
1 30 1
2012-06-08protein level
1 37 1
2012-05-07protein level
1 27 1
2012-04-10protein level
1 27 1
2012-01-13protein level
1 15 1
2011-12-20protein level
1 15 1
2011-11-11protein level
1 15 1
2011-08-23protein level
1 15 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00308-1
0 37 4 98849.8502
NX_O00308-2
1 30 4 86253.1755
NX_O00308-3
1 16 3 51046.2051
NX_O00308-4
1 13 0 35226.6955
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743923,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-743923,EBI-3861591 SMAD7  
  .cellular response to transforming growth factor beta stimulus
.ventricular septum morphogenesis
.negative regulation of pathway-restricted SMAD protein phosphorylation
  + 32 more...
.I-SMAD binding
.activin binding
.metal ion binding
  + 6 more...
.protein complex
.plasma membrane
.cytosol
  + 4 more...
3 EBI-743923,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
4 EBI-743923,EBI-2967304 ADARB1  
  .regulation of cell cycle
.defense response to virus
.innate immune response
  + 10 more...
.metal ion binding
.poly(A) RNA binding
.adenosine deaminase activity
  + 4 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
5 EBI-743923,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
6 EBI-743923,EBI-475687 POU5F1  
  .regulation of methylation-dependent chromatin silencing
.regulation of heart induction by regulation of canonical Wnt signaling pathway
.negative regulation of gene silencing by miRNA
  + 16 more...
.poly(A) RNA binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.cytosol
.cytoplasm
.transcription factor complex
  + 2 more...
7 EBI-743923,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
8 EBI-743923,EBI-10240775 LGALS9B  
  .N/A .carbohydrate binding .N/A
9 EBI-743923,EBI-1245329 ANKRD44  
  .N/A .N/A .N/A
10 EBI-743923,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
11 EBI-743923,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
12 EBI-743923,EBI-6257312 RUSC1  
  .positive regulation of signal transduction
.protein polyubiquitination
.SH3/SH2 adaptor activity
.actin binding
.postsynaptic membrane
.cytoplasmic vesicle
.cell junction
  + 8 more...
13 EBI-743923,EBI-350517 PDLIM7  
  .positive regulation of osteoblast differentiation
.cell differentiation
.actin cytoskeleton organization
  + 3 more...
.zinc ion binding .actin cytoskeleton
.focal adhesion
.cytoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites100
bladder33
blood57
bone97
bone marrow41
brain90
cervix41
connective tissue160
embryonic tissue37
esophagus49
eye43
heart11
intestine25
kidney52
liver9
lung41
lymph158
lymph node33
mammary gland52
mouth30
muscle216
ovary39
pancreas14
pituitary gland60
placenta84
prostate79
skin23
stomach41
testis82
thymus37
thyroid42
tonsil58
trachea811
umbilical cord726
uterus47
vascular77
Health State
TissuesTPM*
normal62
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma96
colorectal tumor17
esophageal tumor57
gastrointestinal tumor59
germ cell tumor53
glioma121
head and neck tumor29
leukemia52
liver tumor10
lung tumor38
lymphoma152
non-neoplasia134
pancreatic tumor19
primitive neuroectodermal tumor of the CNS78
prostate cancer105
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor151
uterine tumor33
Developmental Stage
TissuesTPM*
adult61
embryoid body28
blastocyst32
neonate321
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.7
adrenal gland20.8
appendix21.1
bone marrow20.7
cerebral cortex15.5
colon25
duodenum21.7
esophagus17.3
gallbladder18.2
heart muscle10.4
kidney24.4
liver7.8
lung25.8
lymph node22.1
ovary19.3
pancreas12.7
placenta20.6
prostate15.3
salivary gland25
skin15.1
small intestine21.5
spleen25.5
stomach23.9
testis19.5
thyroid gland22.5
urinary bladder18.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602308, gene) Ww domain-containing protein 2; WWP2OMIM


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