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> Protein (NX_O00330)
Protein (NX_O00330)
Protein
Gene SymbolPDHX to neXtProt (NX_O00330)
DescriptionPyruvate dehydrogenase protein X component, mitochondrial
Chromosome11
Location11p13 (34937376 ~ 35042138) to Ensembl
Sequene Features : Isoforms 3, Variants 71, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular metabolic process
.regulation of acetyl-CoA biosynthetic process from pyruvate
.pyruvate metabolic process
.transferase activity, transferring acyl groups .mitochondrial matrix
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 71 6
2014-09-19protein level
3 63 6
2014-05-27protein level
3 63 6
2014-02-25protein level
2 61 5
2013-12-09protein level
2 41 5
2013-11-01protein level
2 40 4
2013-09-12protein level
2 40 4
2013-08-17protein level
2 40 4
2013-07-15protein level
2 27 4
2013-06-11protein level
2 27 4
2013-02-12protein level
2 20 3
2012-12-20protein level
1 20 2
2012-10-30protein level
1 27 2
2012-10-07protein level
1 27 2
2012-08-24protein level
1 27 2
2012-07-28protein level
1 28 2
2012-06-08protein level
1 41 2
2012-05-07protein level
1 39 2
2012-04-10protein level
1 39 2
2012-01-13protein level
1 36 2
2011-12-20protein level
1 36 2
2011-11-11protein level
1 36 2
2011-08-23protein level
1 36 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00330-1
0 23 0 54088.6281
NX_O00330-2
1 14 0 29887.5808
NX_O00330-3
2 20 0 51428.0315
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751566,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites426
bladder167
blood81
bone41
bone marrow123
brain98
cervix41
connective tissue40
embryonic tissue51
esophagus99
eye23
heart201
intestine60
kidney52
larynx42
liver77
lung11
lymph22
lymph node33
mammary gland13
mouth45
muscle103
nerve128
ovary39
pancreas28
pharynx73
pituitary gland60
placenta52
prostate26
salivary gland246
skin47
spleen93
stomach73
testis75
thymus25
thyroid21
trachea19
uterus56
vascular58
Health State
TissuesTPM*
normal68
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor185
germ cell tumor68
glioma37
head and neck tumor7
kidney tumor58
leukemia95
liver tumor72
lymphoma41
non-neoplasia93
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult46
embryoid body28
blastocyst65
neonate128
fetus35
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland20.9
appendix12.1
bone marrow4.5
cerebral cortex21.7
colon18.8
duodenum18.3
esophagus16.7
gallbladder12.3
heart muscle62.2
kidney19.2
liver15.9
lung11.5
lymph node12.2
ovary10.5
pancreas10.3
placenta23.1
prostate17.3
salivary gland15.3
skin9.9
small intestine14
spleen9.4
stomach18
testis25.4
thyroid gland14.6
urinary bladder16.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#245349, phenotype) Pyruvate dehydrogenase e3-binding protein deficiency; PDHXDOMIM
2(*608769, gene) Pyruvate dehydrogenase complex, component x; PDHXOMIM


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