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> Protein (NX_O00401)
Protein (NX_O00401)
Protein
Gene SymbolWASL to neXtProt (NX_O00401)
DescriptionNeural Wiskott-Aldrich syndrome protein
Chromosome7
Location7q31.32 (123321989 ~ 123389121) to Ensembl
Sequene Features : Isoforms 1, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 64 7
2014-09-19protein level
1 52 7
2014-05-27protein level
1 52 7
2014-02-25protein level
1 50 6
2013-12-09protein level
1 41 6
2013-11-01protein level
1 39 6
2013-09-12protein level
1 39 6
2013-08-17protein level
1 39 6
2013-07-15protein level
1 26 5
2013-06-11protein level
1 26 5
2013-02-12protein level
1 4 4
2012-12-20protein level
1 4 4
2012-10-30protein level
1 4 4
2012-10-07protein level
1 4 4
2012-08-24protein level
1 1 4
2012-07-28protein level
1 1 4
2012-06-08protein level
1 9 4
2012-05-07protein level
1 9 4
2012-04-10protein level
1 9 4
2012-01-13protein level
1 11 4
2011-12-20protein level
1 11 4
2011-11-11protein level
1 11 4
2011-08-23protein level
1 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00401-1
24 0 0 54792.5886
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-957615,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-957615,EBI-351829 ARPC3  
  .ephrin receptor signaling pathway
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.structural constituent of cytoskeleton .extracellular exosome
.lamellipodium
.membrane
  + 4 more...
3 EBI-957615,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
4 EBI-957615,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
5 EBI-957615,EBI-1222956 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
6 EBI-957615,EBI-373337 RNF8  
  .protein K48-linked ubiquitination
.histone H2A K63-linked ubiquitination
.protein K63-linked ubiquitination
  + 16 more...
.protein homodimerization activity
.histone binding
.ubiquitin protein ligase binding
  + 4 more...
.site of double-strand break
.midbody
.nucleolus
  + 3 more...
7 EBI-957615,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
8 EBI-957615,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
9 EBI-957615,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
10 EBI-957615,EBI-372594 CIB1  
  .positive regulation of male germ cell proliferation
.cellular response to nerve growth factor stimulus
.positive regulation of substrate adhesion-dependent cell spreading
  + 40 more...
.protein anchor
.protein serine/threonine kinase inhibitor activity
.Ras GTPase binding
  + 2 more...
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
11 EBI-957615,EBI-6285694 RHOJ  
  .retina vasculature morphogenesis in camera-type eye
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.cytosol
12 EBI-957615,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder133
bone27
bone marrow41
brain66
cervix61
connective tissue13
embryonic tissue32
eye14
heart22
intestine34
kidney75
liver34
lung29
lymph node11
mammary gland19
mouth60
muscle37
nerve128
ovary39
pancreas60
parathyroid97
placenta70
prostate10
skin75
stomach41
testis9
thyroid21
trachea19
uterus60
vascular38
Health State
TissuesTPM*
normal2
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor33
germ cell tumor37
glioma74
head and neck tumor7
kidney tumor29
leukemia21
liver tumor41
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
skin tumor15
soft tissue/muscle tissue tumor55
uterine tumor55
Developmental Stage
TissuesTPM*
adult19
embryoid body28
blastocyst48
fetus28
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.2
adrenal gland25.4
appendix13.3
bone marrow3.3
cerebral cortex31.3
colon39.4
duodenum33.1
esophagus28.7
gallbladder30
heart muscle13.7
kidney37
liver23.8
lung19.8
lymph node7.7
ovary32.3
pancreas13.7
placenta31.2
prostate23.6
salivary gland15.9
skin15
small intestine37
spleen14.7
stomach27.2
testis24.8
thyroid gland33.7
urinary bladder32.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusLow
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605056, gene) Wiskott-aldrich syndrome gene-like; WASLOMIM


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