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> Protein (NX_O00410)
Protein (NX_O00410)
Protein
Gene SymbolIPO5 to neXtProt (NX_O00410)
DescriptionImportin-5
Chromosome13
Location13q32.2 (98605912 ~ 98676551) to Ensembl
Sequene Features : Isoforms 3, Variants 114, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to amino acid stimulus
.positive regulation of protein import into nucleus
.negative regulation of GTPase activity
  + 3 more...
.poly(A) RNA binding
.protein transporter activity
.Ran GTPase binding
.GTPase inhibitor activity
.intracellular membrane-bounded organelle
.nuclear membrane
.membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 114 7
2014-09-19protein level
3 76 7
2014-05-27protein level
3 76 7
2014-02-25protein level
3 76 7
2013-12-09protein level
3 64 7
2013-11-01protein level
3 56 6
2013-09-12protein level
3 56 6
2013-08-17protein level
3 56 6
2013-07-15protein level
3 35 3
2013-06-11protein level
3 35 3
2013-02-12protein level
3 20 11
2012-12-20protein level
3 20 11
2012-10-30protein level
3 25 11
2012-10-07protein level
3 25 4
2012-08-24protein level
3 24 4
2012-07-28protein level
3 24 4
2012-06-08protein level
3 27 4
2012-05-07protein level
3 19 4
2012-04-10protein level
3 19 4
2012-01-13protein level
3 20 4
2011-12-20protein level
3 20 4
2011-11-11protein level
3 20 4
2011-08-23protein level
3 20 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00410-1
1 52 1 123549.5132
NX_O00410-2
0 48 1 116906.119
NX_O00410-3
2 52 1 125463.412
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356424,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-356424,EBI-350806 RPL7  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.protein homodimerization activity
.structural constituent of ribosome
  + 3 more...
.extracellular exosome
.ribonucleoprotein complex
.cytosolic large ribosomal subunit
  + 6 more...
3 EBI-356424,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
4 EBI-356424,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
5 EBI-356424,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
6 EBI-356424,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites401
bladder133
blood89
bone600
bone marrow266
brain163
cervix350
connective tissue120
ear248
embryonic tissue399
esophagus148
eye186
heart189
intestine189
kidney237
larynx42
liver253
lung140
lymph270
lymph node456
mammary gland132
mouth287
muscle150
ovary187
pancreas98
parathyroid145
pharynx49
pituitary gland121
placenta144
prostate184
salivary gland493
skin128
spleen131
stomach167
testis1043
thymus301
thyroid1416
trachea695
umbilical cord290
uterus189
vascular290
Health State
TissuesTPM*
normal199
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor171
cervical tumor492
chondrosarcoma374
colorectal tumor284
esophageal tumor173
gastrointestinal tumor244
germ cell tumor349
glioma195
head and neck tumor635
kidney tumor174
leukemia190
liver tumor416
lung tumor165
lymphoma235
non-neoplasia51
ovarian tumor144
pancreatic tumor95
primitive neuroectodermal tumor of the CNS165
prostate cancer173
retinoblastoma279
skin tumor135
soft tissue/muscle tissue tumor71
uterine tumor144
Developmental Stage
TissuesTPM*
adult204
embryoid body414
blastocyst455
neonate128
fetus228
infant85
juvenile413
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.9
adrenal gland32.1
appendix42.3
bone marrow35.1
cerebral cortex42.4
colon41
duodenum25.8
esophagus45.8
gallbladder39.5
heart muscle49.7
kidney37.6
liver25.9
lung30.8
lymph node48.6
ovary78.6
pancreas34.8
placenta35.6
prostate34.5
salivary gland26.9
skin30.7
small intestine25.8
spleen32.9
stomach29.1
testis197
thyroid gland66.2
urinary bladder47.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602008, gene) Ran-binding protein 5; RANBP5OMIM


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