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> Protein (NX_O00444)
Protein (NX_O00444)
Protein
Gene SymbolPLK4 to neXtProt (NX_O00444)
DescriptionSerine/threonine-protein kinase PLK4
Chromosome4
Location4q28.2 (128802016 ~ 128820350) to Ensembl
Sequene Features : Isoforms 3, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.de novo centriole assembly
.trophoblast giant cell differentiation
.positive regulation of centriole replication
  + 5 more...
.ATP binding
.protein serine/threonine kinase activity
.deuterosome
.cleavage furrow
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 96 2
2014-09-19protein level
3 68 2
2014-05-27protein level
3 68 2
2014-02-25protein level
3 68 2
2013-12-09protein level
3 52 2
2013-11-01protein level
3 51 2
2013-09-12protein level
3 51 2
2013-08-17protein level
3 51 2
2013-07-15protein level
3 33 2
2013-06-11protein level
3 33 2
2013-02-12protein level
3 16 33
2012-12-20protein level
3 17 33
2012-10-30protein level
3 21 33
2012-10-07protein level
3 21 11
2012-08-24protein level
3 21 11
2012-07-28protein level
3 21 11
2012-06-08protein level
3 32 11
2012-05-07protein level
3 29 11
2012-04-10protein level
3 29 11
2012-01-13protein level
3 25 11
2011-12-20protein level
3 25 11
2011-11-11protein level
3 25 11
2011-08-23protein level
3 25 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00444-1
0 45 0 108903.072
NX_O00444-2
1 44 0 105187.0989
NX_O00444-3
0 42 0 104569.8241
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746202,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
2 EBI-746202,EBI-718116 ARR3  
  .visual perception
.signal transduction
.endocytosis
.regulation of protein phosphorylation
.N/A .synapse
.cytoplasm
.photoreceptor inner segment
.photoreceptor outer segment
3 EBI-746202,EBI-742350 TCEB3  
  .positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
4 EBI-746202,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood8
bone27
bone marrow82
brain8
connective tissue6
embryonic tissue61
esophagus49
eye9
intestine12
kidney28
lung2
lymph22
lymph node44
mammary gland19
mouth15
muscle28
pancreas4
placenta17
prostate10
skin14
stomach10
testis94
thymus50
trachea19
uterus12
vascular19
Health State
TissuesTPM*
normal20
adrenal tumor79
chondrosarcoma24
esophageal tumor57
gastrointestinal tumor16
germ cell tumor18
glioma9
head and neck tumor7
kidney tumor14
leukemia63
lymphoma13
ovarian tumor13
pancreatic tumor9
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult13
embryoid body42
blastocyst130
neonate64
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.9
adrenal gland1.8
appendix7.8
bone marrow24.5
cerebral cortex1.4
colon5
duodenum4.7
esophagus5.7
gallbladder1.4
kidney1.1
lung1.9
lymph node10.6
ovary2
placenta5
prostate1.7
skin4.5
small intestine4.2
spleen3.1
stomach2.4
testis28.7
thyroid gland1.2
urinary bladder3.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605031, gene) Polo-like kinase 4; PLK4OMIM


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