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> Protein (NX_O00459)
Protein (NX_O00459)
Protein
Gene SymbolPIK3R2 to neXtProt (NX_O00459)
DescriptionPhosphatidylinositol 3-kinase regulatory subunit beta
Chromosome19
Location19p13.11 (18263928 ~ 18281350) to Ensembl
Sequene Features : Isoforms 1, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 72 4
2014-09-19protein level
1 42 3
2014-05-27protein level
1 42 4
2014-02-25protein level
1 43 4
2013-12-09protein level
1 32 4
2013-11-01protein level
1 30 4
2013-09-12protein level
1 30 4
2013-08-17protein level
1 30 4
2013-07-15protein level
1 25 4
2013-06-11protein level
1 25 4
2013-02-12protein level
1 11 9
2012-12-20protein level
1 11 8
2012-10-30protein level
1 16 8
2012-10-07protein level
1 16 8
2012-08-24protein level
1 16 8
2012-07-28protein level
1 16 8
2012-06-08protein level
1 13 8
2012-05-07protein level
1 13 8
2012-04-10protein level
1 13 8
2012-01-13protein level
1 9 8
2011-12-20protein level
1 9 8
2011-11-11protein level
1 9 6
2011-08-23protein level
1 9 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00459-1
37 0 1 81494.6895
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346930,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-346930,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-346930,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-346930,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-346930,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
6 EBI-346930,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
7 EBI-346930,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
8 EBI-346930,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
9 EBI-346930,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
10 EBI-346930,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
11 EBI-346930,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
12 EBI-346930,EBI-2609540 PIK3CB  
  .regulation of clathrin-mediated endocytosis
.platelet aggregation
.cell chemotaxis
  + 34 more...
.phosphatidylinositol-4,5-bisphosphate 3-kinase activity
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.phosphatidylinositol 3-kinase activity
  + 2 more...
.phosphatidylinositol 3-kinase complex
.plasma membrane
.cytosol
  + 2 more...
13 EBI-346930,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
14 EBI-346930,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
15 EBI-346930,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
16 EBI-346930,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
17 EBI-346930,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
18 EBI-346930,EBI-740680 DYDC1  
  .N/A .N/A .N/A
19 EBI-346930,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
20 EBI-346930,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood8
bone13
brain70
embryonic tissue65
eye43
intestine90
kidney47
larynx170
liver9
lung41
lymph22
mammary gland39
muscle47
ovary266
pancreas103
parathyroid48
pituitary gland60
placenta21
prostate58
salivary gland296
skin104
spleen37
stomach20
testis34
uterus56
vascular19
Health State
TissuesTPM*
normal27
bladder carcinoma56
breast (mammary gland) tumor53
colorectal tumor88
gastrointestinal tumor33
germ cell tumor75
glioma279
head and neck tumor74
kidney tumor72
leukemia10
liver tumor10
lung tumor68
lymphoma13
non-neoplasia10
ovarian tumor144
pancreatic tumor57
primitive neuroectodermal tumor of the CNS228
prostate cancer105
retinoblastoma107
skin tumor143
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult31
embryoid body57
blastocyst97
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7
adrenal gland19
appendix9.9
bone marrow10.6
cerebral cortex23.7
colon17.7
duodenum22.5
esophagus17.8
gallbladder14.7
heart muscle11.5
kidney16.9
liver4.3
lung9.9
lymph node7.5
ovary20
pancreas7.2
placenta10.5
prostate14.2
salivary gland13.2
skin24.9
small intestine18.8
spleen9.7
stomach17.8
testis15.6
thyroid gland10.4
urinary bladder18.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*603157, gene) Phosphatidylinositol 3-kinase, regulatory subunit 2; PIK3R2OMIM
2(-603387, phenotype) Megalencephaly polymicrogyria-polydactyly hydrocephalus syndrome;OMIM


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