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> Protein (NX_O00462)
Protein (NX_O00462)
Protein
Gene SymbolMANBA to neXtProt (NX_O00462)
DescriptionBeta-mannosidase
Chromosome4
Location4q24 (103552660 ~ 103682151) to Ensembl
Sequene Features : Isoforms 1, Variants 104, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mannan catabolic process
.glycoprotein catabolic process
.cellular protein modification process
.carbohydrate metabolic process
.beta-mannosidase activity .intracellular membrane-bounded organelle
.lysosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 104 8
2014-09-19protein level
1 84 8
2014-05-27protein level
1 84 8
2014-02-25protein level
1 83 8
2013-12-09protein level
1 64 8
2013-11-01protein level
1 61 8
2013-09-12protein level
1 61 8
2013-08-17protein level
1 61 8
2013-07-15protein level
1 45 8
2013-06-11protein level
1 45 8
2013-02-12protein level
1 21 8
2012-12-20protein level
1 19 8
2012-10-30protein level
1 26 8
2012-10-07protein level
1 26 8
2012-08-24protein level
1 19 8
2012-07-28protein level
1 19 8
2012-06-08protein level
1 20 8
2012-05-07protein level
1 20 8
2012-04-10protein level
1 20 8
2012-01-13protein level
1 17 8
2011-12-20protein level
1 17 8
2011-11-11protein level
1 17 8
2011-08-23protein level
1 17 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00462-1
41 0 0 100830.5204
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood65
bone marrow41
brain20
connective tissue26
ear62
embryonic tissue46
esophagus49
eye14
heart11
intestine17
kidney33
liver4
lung23
mammary gland46
mouth30
muscle28
pancreas32
pharynx24
pituitary gland181
placenta56
prostate26
salivary gland49
skin9
spleen37
stomach52
testis43
thymus112
thyroid107
trachea96
uterus38
vascular38
Health State
TissuesTPM*
normal25
breast (mammary gland) tumor64
chondrosarcoma12
colorectal tumor26
esophageal tumor57
gastrointestinal tumor42
germ cell tumor72
glioma46
head and neck tumor37
kidney tumor43
leukemia52
lung tumor29
non-neoplasia41
pancreatic tumor19
prostate cancer28
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult38
embryoid body85
blastocyst16
neonate64
fetus19
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10
adrenal gland16.6
appendix12.8
bone marrow19.6
cerebral cortex6.8
colon9.9
duodenum7.5
esophagus7
gallbladder17.8
heart muscle7.4
kidney11.1
liver6.8
lung16.9
lymph node13.9
ovary14.6
pancreas6.4
placenta25.9
prostate10.4
salivary gland17.3
skin5.6
small intestine8.1
spleen16.2
stomach12.4
testis4.8
thyroid gland22
urinary bladder14.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#248510, phenotype) Mannosidosis, beta a, lysosomal; MANSBOMIM
2(*609489, gene) Mannosidase, beta a, lysosomal; MANBAOMIM


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