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> Protein (NX_O00463)
Protein (NX_O00463)
Protein
Gene SymbolTRAF5 to neXtProt (NX_O00463)
DescriptionTNF receptor-associated factor 5
Chromosome1
Location1q32.2 (211499957 ~ 211548288) to Ensembl
Sequene Features : Isoforms 3, Variants 77, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 77 2
2014-09-19protein level
3 66 2
2014-05-27protein level
1 66 2
2014-02-25protein level
1 66 2
2013-12-09protein level
1 50 2
2013-11-01protein level
1 44 2
2013-09-12protein level
1 44 2
2013-08-17protein level
1 44 2
2013-07-15protein level
1 37 0
2013-06-11protein level
1 37 0
2013-02-12protein level
1 24 0
2012-12-20protein level
1 25 0
2012-10-30protein level
1 30 0
2012-10-07protein level
1 30 0
2012-08-24protein level
1 28 0
2012-07-28protein level
1 28 0
2012-06-08protein level
1 29 0
2012-05-07protein level
1 20 0
2012-04-10protein level
1 20 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00463-1
1 31 0 64363.935
NX_O00463-2
1 31 0 65595.541
NX_O00463-3
0 27 0 52124.1003
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-523498,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-523498,EBI-711626 SERPINB9  
  .cellular response to estrogen stimulus
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
  + 7 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.serine-type endopeptidase inhibitor activity
.protease binding
.extracellular exosome
.membrane
.cytosol
  + 4 more...
3 EBI-523498,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
4 EBI-523498,EBI-1046596 SEC13  
  .membrane organization
.mRNA transport
.COPII vesicle coating
  + 9 more...
.N/A .extracellular exosome
.nuclear pore outer ring
.ER to Golgi transport vesicle membrane
  + 4 more...
5 EBI-523498,EBI-398920 SRSF1  
  .cardiac muscle contraction
.regulation of mRNA splicing, via spliceosome
.regulation of mRNA stability
  + 13 more...
.poly(A) RNA binding
.mRNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.nuclear speck
  + 3 more...
6 EBI-523498,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
7 EBI-523498,EBI-10179508 ENOX2  
  .oxidation-reduction process
.regulation of growth
.cell growth
.ultradian rhythm
.protein disulfide oxidoreductase activity
.nucleic acid binding
.nucleotide binding
.external side of plasma membrane
.cytosol
.extracellular space
8 EBI-523498,EBI-10179526 CCDC184  
  .N/A .N/A .cytoplasm
9 EBI-523498,EBI-724630 ZFAND6  
  .cellular response to tumor necrosis factor
.regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of apoptotic process
  + 2 more...
.polyubiquitin binding
.zinc ion binding
.DNA binding
.cytoplasm
10 EBI-523498,EBI-1056653 TNFRSF14  
  .positive regulation of T cell migration
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 7 more...
.ubiquitin protein ligase binding
.tumor necrosis factor-activated receptor activity
.virus receptor activity
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
11 EBI-523498,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
12 EBI-523498,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
13 EBI-523498,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood8
bone marrow20
brain8
cervix103
embryonic tissue32
eye4
intestine21
kidney9
liver9
lung17
lymph node144
mammary gland19
muscle9
ovary9
pancreas32
parathyroid339
pharynx49
placenta17
prostate31
skin14
stomach20
testis25
thymus75
thyroid21
trachea19
uterus94
vascular19
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor32
cervical tumor28
colorectal tumor26
gastrointestinal tumor8
germ cell tumor7
head and neck tumor7
kidney tumor29
leukemia21
liver tumor20
lung tumor19
lymphoma27
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult24
embryoid body28
blastocyst48
neonate32
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland6.3
appendix31
bone marrow5.2
cerebral cortex2.9
colon12
duodenum8.1
esophagus8.4
gallbladder15.8
heart muscle3.7
kidney4.4
liver1.6
lung9.7
lymph node53.2
ovary5.2
pancreas11.8
placenta7
prostate12.7
salivary gland10.5
skin3.5
small intestine11.8
spleen28.5
stomach13.9
testis11.2
thyroid gland2.9
urinary bladder16.5
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowHigh
bronchusLow
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderLow
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleLow
liverLow
lungLow
lymph nodeLow
nasopharynxLow
oral mucosaLow
pancreasLow
parathyroid glandLow
placentaLow
prostateMedium
rectumLow
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Low
small intestineLow
spleenHigh
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602356, gene) Tnf receptor-associated factor 5; TRAF5OMIM


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