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> Protein (NX_O00522)
Protein (NX_O00522)
Protein
Gene SymbolKRIT1 to neXtProt (NX_O00522)
DescriptionKrev interaction trapped protein 1
Chromosome7
Location7q21.2 (91828283 ~ 91875480) to Ensembl
Sequene Features : Isoforms 3, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell apoptotic process
.regulation of establishment of cell polarity
.regulation of catalytic activity
  + 7 more...
.protein complex binding
.GTPase regulator activity
.microtubule binding
.phosphatidylinositol-4,5-bisphosphate binding
.cell-cell junction
.plasma membrane
.microtubule
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 78 1
2014-09-19protein level
3 60 1
2014-05-27protein level
3 60 1
2014-02-25protein level
3 60 1
2013-12-09protein level
3 48 1
2013-11-01protein level
3 47 1
2013-09-12protein level
3 47 1
2013-08-17protein level
3 47 1
2013-07-15protein level
3 31 1
2013-06-11protein level
3 31 1
2013-02-12protein level
3 19 0
2012-12-20protein level
3 21 0
2012-10-30protein level
3 24 0
2012-10-07protein level
3 24 0
2012-08-24protein level
3 17 0
2012-07-28protein level
3 16 0
2012-06-08protein level
3 19 0
2012-05-07protein level
3 19 0
2012-04-10protein level
2 19 0
2012-01-13protein level
2 12 0
2011-12-20protein level
2 12 0
2011-11-11protein level
2 12 0
2011-08-23protein level
2 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00522-1
0 35 0 84294.2018
NX_O00522-2
1 26 0 60906.0488
NX_O00522-3
0 32 0 78599.5588
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1573121,EBI-1573056 CCM2  
  .endothelial tube morphogenesis
.blood vessel endothelial cell differentiation
.pericardium development
  + 9 more...
.N/A .protein complex
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder200
blood32
bone27
bone marrow61
brain50
connective tissue26
embryonic tissue79
esophagus49
eye28
intestine56
kidney61
larynx42
liver24
lung29
lymph node55
mammary gland39
mouth226
muscle18
ovary19
pancreas4
pharynx24
pituitary gland60
placenta24
prostate26
skin56
spleen112
stomach52
testis96
thymus87
thyroid85
tonsil58
trachea96
uterus43
vascular38
Health State
TissuesTPM*
normal45
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor53
chondrosarcoma24
colorectal tumor88
esophageal tumor57
gastrointestinal tumor8
germ cell tumor94
head and neck tumor141
kidney tumor87
liver tumor20
lung tumor19
non-neoplasia10
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult35
embryoid body114
blastocyst48
neonate128
fetus43
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.4
adrenal gland21.7
appendix22.1
bone marrow6.8
cerebral cortex19.5
colon17.9
duodenum18.8
esophagus19.5
gallbladder23
heart muscle20
kidney19.9
liver10.6
lung20.1
lymph node23.6
ovary27.7
pancreas9.1
placenta19.9
prostate19.2
salivary gland16.1
skin23.3
small intestine16.3
spleen23.7
stomach18.7
testis30.3
thyroid gland32.5
urinary bladder21.6
Tissues
TissuesExpression level
appendixLow
colonLow
duodenumLow
epididymisLow
rectumLow
skin 2Low
small intestineLow
smooth muscleLow
stomach 1Low
testisLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#116860, phenotype) Cerebral cavernous malformations; CCMOMIM
2(*604214, gene) Krev interaction trapped 1; KRIT1OMIM


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