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> Protein (NX_O00555)
Protein (NX_O00555)
Protein
Gene SymbolCACNA1A to neXtProt (NX_O00555)
DescriptionVoltage-dependent P/Q-type calcium channel subunit alpha-1A
Chromosome19
Location19p13.2 (13317256 ~ 13734804) to Ensembl
Sequene Features : Isoforms 8, Variants 287, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane depolarization during action potential
.calcium ion import
.rhythmic synaptic transmission
  + 37 more...
.metal ion binding
.syntaxin binding
.high voltage-gated calcium channel activity
.voltage-gated calcium channel activity
.neuronal cell body
.cell projection
.dendrite
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 287 3
2014-09-19protein level
8 207 3
2014-05-27protein level
8 206 4
2014-02-25protein level
8 206 4
2013-12-09protein level
8 171 4
2013-11-01protein level
8 171 4
2013-09-12protein level
8 171 8
2013-08-17protein level
8 171 8
2013-07-15protein level
8 106 7
2013-06-11protein level
8 106 7
2013-02-12protein level
7 63 41
2012-12-20protein level
7 66 41
2012-10-30protein level
7 72 41
2012-10-07protein level
7 72 7
2012-08-24protein level
7 60 7
2012-07-28protein level
7 60 7
2012-06-08protein level
7 59 7
2012-05-07protein level
7 59 7
2012-04-10protein level
7 58 7
2012-01-13protein level
7 58 7
2011-12-20protein level
7 59 7
2011-11-11protein level
7 59 7
2011-08-23protein level
7 59 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00555-1
0 89 10 282184.4311
NX_O00555-2
0 79 10 256767.156
NX_O00555-3
0 78 10 256612.1842
NX_O00555-4
0 88 10 282029.4593
NX_O00555-5
0 79 10 255347.3577
NX_O00555-6
0 89 10 280764.6328
NX_O00555-7
2 77 10 254179.0352
NX_O00555-8
1 87 10 282383.5262
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-766279,EBI-949020 MATN2  
  .response to axon injury
.dendrite regeneration
.glial cell migration
  + 2 more...
.calcium ion binding .basement membrane
.proteinaceous extracellular matrix
2 EBI-766279,EBI-947597 MEGF6  
  .N/A .calcium ion binding .extracellular region
3 EBI-766279,EBI-5655937 DNAJB5  
  .response to unfolded protein
.protein folding
.negative regulation of transcription from RNA polymerase II promoter
.chaperone binding .cytosol
.nucleus
4 EBI-766279,EBI-3389315 LPHN1  
  .positive regulation of synapse maturation
.calcium-mediated signaling using intracellular calcium source
.G-protein coupled receptor signaling pathway
.heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
.cell adhesion molecule binding
.carbohydrate binding
.latrotoxin receptor activity
.G-protein coupled receptor activity
.synapse
.neuron projection
.presynaptic membrane
  + 5 more...
5 EBI-766279,EBI-5915931 BZRAP1  
  .glutamate secretion
.neurotransmitter secretion
.synaptic transmission
.benzodiazepine receptor binding .cytosol
.mitochondrion
.cytoplasm
6 EBI-766279,EBI-722264 HIVEP1  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.mitochondrion
.nucleoplasm
.nucleus
7 EBI-766279,EBI-1051424 UQCRC2  
  .small molecule metabolic process
.cellular metabolic process
.respiratory electron transport chain
  + 2 more...
.metal ion binding
.metalloendopeptidase activity
.extracellular exosome
.mitochondrial respiratory chain complex III
.mitochondrial inner membrane
.mitochondrion
8 EBI-766279,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
9 EBI-766279,EBI-712871 YLPM1  
  .regulation of telomere maintenance .poly(A) RNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.nuclear speck
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-766279,EBI-348169 CSNK2B  
  .endothelial tube morphogenesis
.regulation of DNA binding
.regulation of protein kinase activity
  + 11 more...
.metal ion binding
.identical protein binding
.protein domain specific binding
  + 4 more...
.extracellular exosome
.protein kinase CK2 complex
.cytosol
  + 2 more...
11 EBI-766279,EBI-3866859 ARHGAP22  
  .regulation of small GTPase mediated signal transduction
.cell differentiation
.small GTPase mediated signal transduction
  + 3 more...
.GTPase activator activity .focal adhesion
.cytosol
.nucleus
12 EBI-766279,EBI-947617 MEGF8  
  .fasciculation of sensory neuron axon
.craniofacial suture morphogenesis
.determination of digestive tract left/right asymmetry
  + 12 more...
.calcium ion binding
.receptor activity
.extracellular exosome
.integral component of membrane
.nucleus
13 EBI-766279,EBI-3866830 AMIGO2  
  .cell-cell adhesion
.negative regulation of programmed cell death
.negative regulation of apoptotic process
  + 3 more...
.N/A .integral component of membrane
.plasma membrane
.nucleus
14 EBI-766279,EBI-3044077 RBM12B  
  .N/A .poly(A) RNA binding
.nucleotide binding
.N/A
15 EBI-766279,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
16 EBI-766279,EBI-947718 LTBP4  
  .regulation of cell differentiation
.growth hormone secretion
.extracellular matrix organization
  + 6 more...
.transforming growth factor beta binding
.glycosaminoglycan binding
.calcium ion binding
  + 2 more...
.extracellular exosome
.extracellular matrix
.extracellular space
  + 2 more...
17 EBI-766279,EBI-355665 TUBB2B  
  .protein polymerization
.'de novo' posttranslational protein folding
.cellular protein metabolic process
  + 3 more...
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.microtubule
.cytoplasm
.nucleus
18 EBI-766279,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain15
embryonic tissue4
eye57
kidney4
lung14
lymph node11
muscle9
ovary29
pancreas23
skin4
testis11
tonsil58
uterus4
Health State
TissuesTPM*
normal13
germ cell tumor15
glioma37
lung tumor19
ovarian tumor13
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult8
fetus5
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1
adrenal gland4.1
cerebral cortex15
colon1.4
duodenum3.4
gallbladder1.1
pancreas2.4
small intestine1.8
stomach9.4
testis3.4
Tissues
TissuesExpression level
cerebral cortexHigh
duodenumMedium
epididymisLow
hippocampusHigh
lateral ventricleHigh
liverMedium
skin 1Low
small intestineMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#108500, phenotype) Episodic ataxia, type 2; EA2OMIM
2(#141500, phenotype) Migraine, familial hemiplegic, 1; FHM1OMIM
3(#183086, phenotype) Spinocerebellar ataxia 6; SCA6OMIM
4(*601011, gene) Calcium channel, voltage-dependent, p/q type, alpha-1a subunit; CACNA1AOMIM


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2014-2019 (C) Yonsei Proteome Research Center