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> Protein (NX_O00560)
Protein (NX_O00560)
Protein
Gene SymbolSDCBP to neXtProt (NX_O00560)
DescriptionSyntenin-1
Chromosome8
Location8q12.1 (59465483 ~ 59495419) to Ensembl
Sequene Features : Isoforms 3, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 33 3
2014-09-19protein level
3 27 3
2014-05-27protein level
3 27 3
2014-02-25protein level
3 27 3
2013-12-09protein level
3 21 3
2013-11-01protein level
3 19 3
2013-09-12protein level
3 19 3
2013-08-17protein level
3 19 3
2013-07-15protein level
3 16 2
2013-06-11protein level
3 16 2
2013-02-12protein level
3 9 15
2012-12-20protein level
3 7 15
2012-10-30protein level
3 11 15
2012-10-07protein level
3 11 5
2012-08-24protein level
3 11 5
2012-07-28protein level
3 11 5
2012-06-08protein level
3 12 5
2012-05-07protein level
3 11 5
2012-04-10protein level
3 11 5
2012-01-13protein level
3 10 5
2011-12-20protein level
3 10 5
2011-11-11protein level
3 10 5
2011-08-23protein level
3 10 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00560-1
0 10 0 32423.8252
NX_O00560-2
1 9 0 32295.767
NX_O00560-3
1 9 0 31741.4259
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-727004,EBI-2682520 ERICH2  
  .N/A .N/A .N/A
2 EBI-727004,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
3 EBI-727004,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
4 EBI-727004,EBI-2130415 TRIM38  
  .protein K48-linked ubiquitination
.interferon-gamma-mediated signaling pathway
.positive regulation of NF-kappaB transcription factor activity
  + 8 more...
.ligase activity
.zinc ion binding
.signal transducer activity
.cytosol
5 EBI-727004,EBI-358858 CDIPT  
  .glycerophospholipid biosynthetic process
.CDP-diacylglycerol metabolic process
.small molecule metabolic process
  + 2 more...
.alcohol binding
.carbohydrate binding
.manganese ion binding
  + 2 more...
.integral component of membrane
.membrane
.plasma membrane
  + 3 more...
6 EBI-727004,EBI-2214136 HMGB3  
  .negative regulation of myeloid cell differentiation
.negative regulation of B cell differentiation
.multicellular organismal development
  + 3 more...
.poly(A) RNA binding
.DNA binding, bending
.double-stranded DNA binding
.chromatin binding
.chromosome
.nucleus
7 EBI-727004,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
8 EBI-727004,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
9 EBI-727004,EBI-10179062 SULT1B1  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 7 more...
.sulfotransferase activity
.aryl sulfotransferase activity
.cytosol
10 EBI-727004,EBI-2515299 SSNA1  
  .ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
.organelle organization
  + 2 more...
.N/A .ciliary basal body
.cytosol
.centrosome
.nucleus
11 EBI-727004,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-727004,EBI-746917 FZD7  
  .cellular response to retinoic acid
.mesenchymal to epithelial transition
.canonical Wnt signaling pathway
  + 15 more...
.Wnt-activated receptor activity
.PDZ domain binding
.Wnt-protein binding
  + 2 more...
.integral component of membrane
.plasma membrane
13 EBI-727004,EBI-5280197 PRPF40A  
  .cell division
.regulation of cytokinesis
.cell migration
  + 5 more...
.poly(A) RNA binding .nuclear speck
.nuclear matrix
.membrane
  + 2 more...
14 EBI-727004,EBI-748664 HSBP1  
  .regulation of cellular response to heat
.endodermal cell differentiation
.cellular response to heat
  + 2 more...
.transcription corepressor activity .cytoskeleton
.nucleoplasm
.nucleus
15 EBI-727004,EBI-746999 KLHL2  
  .protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
16 EBI-727004,EBI-2909270 KCNH1  
  .potassium ion transmembrane transport
.regulation of membrane potential
.regulation of cell proliferation
  + 3 more...
.delayed rectifier potassium channel activity
.phosphorelay sensor kinase activity
.early endosome membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
  + 4 more...
17 EBI-727004,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
18 EBI-727004,EBI-743949 NADK  
  .ATP metabolic process
.small molecule metabolic process
.NAD metabolic process
  + 4 more...
.metal ion binding
.ATP binding
.NAD+ kinase activity
.cytosol
19 EBI-727004,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
20 EBI-727004,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
21 EBI-727004,EBI-748210 HPRT1  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.dendrite morphogenesis
  + 23 more...
.guanine phosphoribosyltransferase activity
.protein homodimerization activity
.hypoxanthine phosphoribosyltransferase activity
  + 2 more...
.extracellular exosome
.cytosol
.cytoplasm
22 EBI-727004,EBI-6875961 CRYAA  
  .protein homooligomerization
.response to stimulus
.negative regulation of apoptotic process
  + 2 more...
.unfolded protein binding
.metal ion binding
.identical protein binding
.structural constituent of eye lens
.extracellular exosome
.cytoplasm
.nucleus
23 EBI-727004,EBI-713279 FTL  
  .membrane organization
.transmembrane transport
.iron ion homeostasis
  + 4 more...
.identical protein binding
.ferric iron binding
.iron ion binding
.extracellular exosome
.membrane
.intracellular ferritin complex
.cytosol
24 EBI-727004,EBI-7181544 LGALS2  
  .N/A .carbohydrate binding
.galactoside binding
.N/A
25 EBI-727004,EBI-357966 HNRNPC  
  .3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
26 EBI-727004,EBI-1056574 COX4I1  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 5 more...
.cytochrome-c oxidase activity .extracellular exosome
.membrane
.mitochondrial inner membrane
  + 2 more...
27 EBI-727004,EBI-1237106 RNH1  
  .regulation of angiogenesis
.negative regulation of catalytic activity
.mRNA catabolic process
.ribonuclease inhibitor activity .extracellular exosome
.angiogenin-PRI complex
.cytoplasm
28 EBI-727004,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
29 EBI-727004,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
30 EBI-727004,EBI-9250559 CDA  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.negative regulation of nucleotide metabolic process
  + 8 more...
.protein homodimerization activity
.zinc ion binding
.cytidine deaminase activity
.nucleoside binding
.cytosol
.extracellular region
31 EBI-727004,EBI-739870 DCTD  
  .nucleobase-containing small molecule metabolic process
.pyrimidine nucleoside biosynthetic process
.small molecule metabolic process
  + 3 more...
.zinc ion binding
.dCMP deaminase activity
.extracellular exosome
.cytosol
32 EBI-727004,EBI-743494 TDO2  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tryptophan catabolic process to acetyl-CoA
  + 2 more...
.metal ion binding
.heme binding
.oxygen binding
  + 2 more...
.cytosol
33 EBI-727004,EBI-975634 CDC34  
  .positive regulation of inclusion body assembly
.protein K48-linked ubiquitination
.response to growth factor
  + 8 more...
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.cytoplasm
.nucleoplasm
.nucleus
34 EBI-727004,EBI-2339348 UBE2A  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.maternal process involved in female pregnancy
  + 11 more...
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.HULC complex
.cytosol
.cytoplasm
  + 3 more...
35 EBI-727004,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
36 EBI-727004,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
37 EBI-727004,EBI-745579 CLK3  
  .protein autophosphorylation
.regulation of RNA splicing
.protein phosphorylation
.poly(A) RNA binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intermediate filament cytoskeleton
.nuclear speck
.membrane
  + 3 more...
38 EBI-727004,EBI-742084 NT5C2  
  .nucleobase-containing small molecule metabolic process
.adenosine metabolic process
.IMP metabolic process
  + 6 more...
.nucleoside phosphotransferase activity
.metal ion binding
.5'-nucleotidase activity
.nucleotide binding
.cytosol
39 EBI-727004,EBI-10212306 SMARCA2  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 9 more...
.transcription regulatory region DNA binding
.DNA-dependent ATPase activity
.ATP binding
  + 3 more...
.nBAF complex
.npBAF complex
.intermediate filament cytoskeleton
  + 5 more...
40 EBI-727004,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
41 EBI-727004,EBI-373310 LSM6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.maturation of SSU-rRNA
.gene expression
  + 4 more...
.poly(A) RNA binding .extracellular exosome
.U4/U6 x U5 tri-snRNP complex
.small nuclear ribonucleoprotein complex
  + 6 more...
42 EBI-727004,EBI-357669 PSMC6  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.proteasome-activating ATPase activity
.protein binding, bridging
.TBP-class protein binding
  + 2 more...
.extracellular exosome
.cytosolic proteasome complex
.nuclear proteasome complex
  + 7 more...
43 EBI-727004,EBI-1053182 SET  
  .negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
44 EBI-727004,EBI-712344 PTS  
  .regulation of nitric-oxide synthase activity
.nitric oxide metabolic process
.small molecule metabolic process
  + 3 more...
.metal ion binding
.identical protein binding
.6-pyruvoyltetrahydropterin synthase activity
.cytosol
.mitochondrion
.cytoplasm
45 EBI-727004,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
46 EBI-727004,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
47 EBI-727004,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
48 EBI-727004,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
49 EBI-727004,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
50 EBI-727004,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
51 EBI-727004,EBI-78203 MAD2L1  
  .positive regulation of mitotic cell cycle spindle assembly checkpoint
.negative regulation of APC-Cdc20 complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 11 more...
.protein homodimerization activity
.identical protein binding
.mitotic spindle
.perinuclear region of cytoplasm
.cytosol
  + 4 more...
52 EBI-727004,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
53 EBI-727004,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
54 EBI-727004,EBI-930865 DMC1  
  .female gamete generation
.spermatid development
.spermatogenesis
  + 7 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.chromosome
.nucleus
.condensed nuclear chromosome
.chromosome, telomeric region
55 EBI-727004,EBI-374260 ELAVL1  
  .regulation of stem cell maintenance
.3'-UTR-mediated mRNA stabilization
.mRNA stabilization
  + 3 more...
.poly(A) RNA binding
.mRNA 3'-UTR AU-rich region binding
.protein kinase binding
  + 6 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
56 EBI-727004,EBI-398885 SRSF7  
  .negative regulation of mRNA splicing, via spliceosome
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.nucleotide binding
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
57 EBI-727004,EBI-10180131 RTN1  
  .neuron differentiation .N/A .integral component of endoplasmic reticulum membrane
.endoplasmic reticulum membrane
58 EBI-727004,EBI-4291069 DAK  
  .fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
.carbohydrate phosphorylation
.regulation of innate immune response
  + 6 more...
.triokinase activity
.metal ion binding
.FAD-AMP lyase (cyclizing) activity
  + 2 more...
.extracellular exosome
.cytosol
.nucleus
59 EBI-727004,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
60 EBI-727004,EBI-2959680 PYCRL  
  .L-proline biosynthetic process .pyrroline-5-carboxylate reductase activity .N/A
61 EBI-727004,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
62 EBI-727004,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
63 EBI-727004,EBI-10247136 BCL2L15  
  .apoptotic process .N/A .cytosol
.nucleus
64 EBI-727004,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
65 EBI-727004,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
66 EBI-727004,EBI-2838246 ANKRD40  
  .N/A .N/A .N/A
67 EBI-727004,EBI-8635816 CT45A5  
  .N/A .N/A .N/A
68 EBI-727004,EBI-3920396 C11orf57  
  .N/A .N/A .N/A
69 EBI-727004,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
70 EBI-727004,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
71 EBI-727004,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
72 EBI-727004,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
73 EBI-727004,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
74 EBI-727004,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
75 EBI-727004,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
76 EBI-727004,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
77 EBI-727004,EBI-2555378 GPATCH11  
  .N/A .nucleic acid binding .N/A
78 EBI-727004,EBI-750700 EIF1AD  
  .N/A .translation initiation factor activity .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
79 EBI-727004,EBI-10268630 SREK1IP1  
  .RNA splicing
.mRNA processing
.zinc ion binding
.nucleic acid binding
.N/A
80 EBI-727004,EBI-715374 PRPF38A  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .precatalytic spliceosome
.nuclear membrane
.nucleus
81 EBI-727004,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
82 EBI-727004,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
83 EBI-727004,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
84 EBI-727004,EBI-742815 FLAD1  
  .small molecule metabolic process
.riboflavin metabolic process
.water-soluble vitamin metabolic process
  + 2 more...
.ATP binding
.FMN adenylyltransferase activity
.plasma membrane
.cytosol
.mitochondrial matrix
.cytoplasm
85 EBI-727004,EBI-8643558 CT45A3  
  .N/A .N/A .N/A
86 EBI-727004,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
87 EBI-727004,EBI-713221 ENOX1  
  .rhythmic process .oxidoreductase activity
.nucleic acid binding
.nucleotide binding
.plasma membrane
.extracellular space
88 EBI-727004,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
89 EBI-727004,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
90 EBI-727004,EBI-762428 ANP32B  
  .palate development
.inner ear development
.positive regulation of protein export from nucleus
  + 5 more...
.RNA polymerase binding
.histone binding
.extracellular exosome
.cytoplasm
.nucleus
91 EBI-727004,EBI-1051152 OSTF1  
  .signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
92 EBI-727004,EBI-10180409 TEKT1  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
93 EBI-727004,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
94 EBI-727004,EBI-10178036 SDCCAG3  
  .retrograde transport, endosome to plasma membrane
.cell division
.regulation of cytokinesis
  + 2 more...
.N/A .recycling endosome
.midbody
.early endosome
.endosome
95 EBI-727004,EBI-740711 TIFA  
  .I-kappaB kinase/NF-kappaB signaling .N/A .N/A
96 EBI-727004,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
97 EBI-727004,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
98 EBI-727004,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
99 EBI-727004,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
100 EBI-727004,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
101 EBI-727004,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
102 EBI-727004,EBI-726822 FAM118B  
  .N/A .N/A .Cajal body
103 EBI-727004,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
104 EBI-727004,EBI-748028 EIF5A2  
  .mRNA transport
.positive regulation of translational termination
.positive regulation of translational elongation
  + 8 more...
.ribosome binding
.translation elongation factor activity
.cytosol
.endoplasmic reticulum membrane
.nuclear pore
105 EBI-727004,EBI-721765 C11orf68  
  .N/A .poly(A) RNA binding .N/A
106 EBI-727004,EBI-1019736 CDCP1  
  .N/A .N/A .integral component of membrane
.plasma membrane
.extracellular region
107 EBI-727004,EBI-723569 DCTPP1  
  .protein homotetramerization
.nucleoside triphosphate catabolic process
.dCTP diphosphatase activity
.nucleoside-triphosphate diphosphatase activity
.identical protein binding
  + 2 more...
.cytosol
108 EBI-727004,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
109 EBI-727004,EBI-746345 ZCCHC17  
  .activation of mitophagy in response to mitochondrial depolarization
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.zinc ion binding
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 2 more...
110 EBI-727004,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
111 EBI-727004,EBI-9091816 RIC8A  
  .basement membrane organization
.cell-cell adhesion involved in gastrulation
.positive regulation of GTPase activity
  + 6 more...
.GTPase activator activity
.guanyl-nucleotide exchange factor activity
.G-protein alpha-subunit binding
.plasma membrane
.cytoplasm
112 EBI-727004,EBI-2824799 LZTFL1  
  .negative regulation of protein localization to ciliary membrane
.negative regulation of protein localization to cilium
.establishment of protein localization to organelle
.organelle organization
.identical protein binding
.protein complex binding
.BBSome
.cytosol
113 EBI-727004,EBI-714918 CUTC  
  .transmembrane transport
.copper ion homeostasis
.protein tetramerization
  + 2 more...
.copper ion binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
114 EBI-727004,EBI-8638992 FAM118A  
  .N/A .N/A .integral component of membrane
115 EBI-727004,EBI-746510 THG1L  
  .protein homotetramerization
.tRNA processing
.tRNA modification
.identical protein binding
.tRNA guanylyltransferase activity
.GTP binding
  + 3 more...
.mitochondrion
116 EBI-727004,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
117 EBI-727004,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
118 EBI-727004,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
119 EBI-727004,EBI-723153 CGGBP1  
  .negative regulation of transcription from RNA polymerase II promoter .double-stranded DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
120 EBI-727004,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
121 EBI-727004,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
122 EBI-727004,EBI-372578 NAGK  
  .carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
123 EBI-727004,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
124 EBI-727004,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
125 EBI-727004,EBI-10180690 CADPS  
  .catecholamine secretion
.synaptic vesicle priming
.vesicle organization
  + 2 more...
.metal ion binding
.protein kinase binding
.lipid binding
.synapse
.cytoplasmic vesicle membrane
.cell junction
.cytosol
126 EBI-727004,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
127 EBI-727004,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland607
ascites200
bladder770
blood1382
bone307
bone marrow697
brain339
cervix247
connective tissue489
ear186
embryonic tissue178
esophagus545
eye67
heart201
intestine155
kidney294
liver277
lung247
lymph45
lymph node111
mammary gland178
mouth166
muscle75
nerve193
ovary78
pancreas196
parathyroid825
pharynx245
pituitary gland242
placenta233
prostate116
salivary gland197
skin417
spleen505
stomach428
testis137
thymus665
thyroid42
trachea617
umbilical cord653
uterus310
vascular909
Health State
TissuesTPM*
normal303
adrenal tumor711
bladder carcinoma796
breast (mammary gland) tumor204
cervical tumor231
chondrosarcoma301
colorectal tumor151
esophageal tumor637
gastrointestinal tumor295
germ cell tumor315
glioma158
head and neck tumor52
kidney tumor290
leukemia381
liver tumor302
lung tumor107
lymphoma110
non-neoplasia548
ovarian tumor65
pancreatic tumor133
primitive neuroectodermal tumor of the CNS204
prostate cancer86
skin tumor550
soft tissue/muscle tissue tumor215
uterine tumor299
Developmental Stage
TissuesTPM*
adult211
embryoid body171
blastocyst65
neonate1931
fetus157
infant425
juvenile269
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue156.5
adrenal gland117.3
appendix153.6
bone marrow137.1
cerebral cortex72.6
colon102
duodenum73.2
esophagus82.8
gallbladder182.9
heart muscle73.5
kidney75.5
liver78.8
lung163.1
lymph node106.5
ovary77.9
pancreas35.1
placenta193.2
prostate63.5
salivary gland80.2
skin49.7
small intestine81.3
spleen146.7
stomach113.8
testis43.8
thyroid gland93.6
urinary bladder157.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602217, gene) Syndecan-binding protein; SDCBPOMIM


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