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> Protein (NX_O00571)
Protein (NX_O00571)
Protein
Gene SymbolDDX3X to neXtProt (NX_O00571)
DescriptionATP-dependent RNA helicase DDX3X
ChromosomeX
LocationXp11.4 (41192651 ~ 41223725) to Ensembl
Sequene Features : Isoforms 2, Variants 119, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 119 22
2014-09-19protein level
2 83 22
2014-05-27protein level
2 83 28
2014-02-25protein level
2 83 26
2013-12-09protein level
2 83 26
2013-11-01protein level
2 82 22
2013-09-12protein level
2 82 24
2013-08-17protein level
2 82 24
2013-07-15protein level
2 64 19
2013-06-11protein level
2 64 19
2013-02-12protein level
2 24 32
2012-12-20protein level
2 24 32
2012-10-30protein level
2 24 32
2012-10-07protein level
2 24 16
2012-08-24protein level
2 22 16
2012-07-28protein level
2 22 16
2012-06-08protein level
2 4 16
2012-05-07protein level
2 6 16
2012-04-10protein level
2 6 16
2012-01-13protein level
1 5 16
2011-12-20protein level
1 5 16
2011-11-11protein level
1 5 14
2011-08-23protein level
1 5 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00571-1
1 12 22 73197.7909
NX_O00571-2
1 12 22 71310.7265
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353779,EBI-995350 DDX58  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 17 more...
.identical protein binding
.zinc ion binding
.ATP binding
  + 4 more...
.ruffle membrane
.actin cytoskeleton
.tight junction
  + 2 more...
2 EBI-353779,EBI-1056162 EIF2S1  
  .activation of mitophagy in response to mitochondrial depolarization
.transmembrane transport
.protein autophosphorylation
  + 8 more...
.poly(A) RNA binding
.ribosome binding
.translation initiation factor activity
.extracellular exosome
.multi-eIF complex
.eukaryotic 48S preinitiation complex
  + 7 more...
3 EBI-353779,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
4 EBI-353779,EBI-366696 EIF3B  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.protein complex scaffold
.translation initiation factor activity
.nucleotide binding
.eukaryotic translation initiation factor 3 complex, eIF3m
.extracellular exosome
.eukaryotic 48S preinitiation complex
  + 5 more...
5 EBI-353779,EBI-73711 EIF4G1  
  .cellular protein metabolic process
.cytokine-mediated signaling pathway
.viral process
  + 8 more...
.poly(A) RNA binding
.translation factor activity, RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 4F complex
.membrane
.cytosol
6 EBI-353779,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
7 EBI-353779,EBI-1046410 NCAPH  
  .cell division
.mitotic chromosome condensation
.mitotic cell cycle
.N/A .membrane
.cytosol
.cytoplasm
  + 2 more...
8 EBI-353779,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
9 EBI-353779,EBI-353741 EIF3C  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.eukaryotic translation initiation factor 3 complex
.cytosol
10 EBI-353779,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland151
ascites251
bladder200
blood114
bone125
bone marrow41
brain209
cervix144
connective tissue67
ear124
embryonic tissue319
esophagus99
eye143
heart78
intestine181
kidney128
larynx85
liver199
lung128
lymph225
lymph node155
mammary gland185
mouth377
muscle75
nerve193
ovary19
pancreas60
parathyroid291
pharynx171
pituitary gland121
placenta208
prostate73
skin151
spleen206
stomach177
testis264
thymus414
thyroid193
tonsil58
trachea1100
umbilical cord72
uterus473
vascular96
Health State
TissuesTPM*
normal178
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma96
colorectal tumor239
esophageal tumor115
gastrointestinal tumor210
germ cell tumor292
glioma46
head and neck tumor283
kidney tumor130
leukemia10
liver tumor270
lung tumor126
lymphoma235
non-neoplasia113
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer96
retinoblastoma193
skin tumor167
soft tissue/muscle tissue tumor223
uterine tumor288
Developmental Stage
TissuesTPM*
adult160
embryoid body357
blastocyst358
neonate64
fetus184
infant42
juvenile269
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue131.7
adrenal gland119.7
appendix119.1
bone marrow176.1
cerebral cortex67.7
colon81.9
duodenum73.9
esophagus108.7
gallbladder118.3
heart muscle71.1
kidney85.4
liver60.5
lung91
lymph node119.9
ovary108.2
pancreas38.2
placenta99.9
prostate59.1
salivary gland59.6
skin78.8
small intestine73
spleen86.1
stomach74.7
testis72.9
thyroid gland116.8
urinary bladder105.5
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusLow
cerebral cortexMedium
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderLow
hippocampusLow
lateral ventricleLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandLow
placentaLow
prostateLow
rectumLow
salivary glandLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300160, gene) Dead/h box 3, x-linked; DDX3XOMIM


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