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> Protein (NX_O00635)
Protein (NX_O00635)
Protein
Gene SymbolTRIM38 to neXtProt (NX_O00635)
DescriptionE3 ubiquitin-protein ligase TRIM38
Chromosome6
Location6p22.2 (25963030 ~ 25987384) to Ensembl
Sequene Features : Isoforms 1, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked ubiquitination
.interferon-gamma-mediated signaling pathway
.positive regulation of NF-kappaB transcription factor activity
  + 8 more...
.ligase activity
.zinc ion binding
.signal transducer activity
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 69 3
2014-09-19protein level
1 58 3
2014-05-27protein level
1 58 3
2014-02-25protein level
1 58 3
2013-12-09protein level
1 46 4
2013-11-01protein level
1 46 4
2013-09-12protein level
1 46 4
2013-08-17protein level
1 46 3
2013-07-15protein level
1 35 0
2013-06-11protein level
1 35 0
2013-02-12protein level
1 16 0
2012-12-20protein level
1 16 0
2012-10-30protein level
1 14 0
2012-10-07protein level
1 14 0
2012-08-24transcript level
1 14 0
2012-07-28transcript level
1 14 0
2012-06-08transcript level
1 15 0
2012-05-07transcript level
1 9 0
2012-04-10transcript level
1 9 0
2012-01-13transcript level
1 9 0
2011-12-20transcript level
1 9 0
2011-11-11transcript level
1 9 0
2011-08-23transcript level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00635-1
20 0 0 53381.0565
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2130415,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-2130415,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
3 EBI-2130415,EBI-712376 RFC5  
  .error-free translesion synthesis
.DNA damage response, detection of DNA damage
.error-prone translesion synthesis
  + 13 more...
.enzyme binding
.ATP binding
.DNA binding
.DNA replication factor C complex
.nucleoplasm
.nucleus
4 EBI-2130415,EBI-356991 HSPA2  
  .negative regulation of inclusion body assembly
.synaptonemal complex disassembly
.protein refolding
  + 5 more...
.glycolipid binding
.unfolded protein binding
.enzyme binding
.ATP binding
.blood microparticle
.extracellular exosome
.CatSper complex
  + 7 more...
5 EBI-2130415,EBI-960169 STXBP1  
  .protein localization to plasma membrane
.platelet aggregation
.long term synaptic depression
  + 19 more...
.poly(A) RNA binding
.identical protein binding
.syntaxin binding
  + 2 more...
.extracellular exosome
.protein complex
.platelet alpha granule
  + 5 more...
6 EBI-2130415,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
7 EBI-2130415,EBI-308511 TSPYL4  
  .nucleosome assembly .N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland60
ascites50
bladder33
blood81
bone marrow82
brain9
connective tissue93
embryonic tissue4
esophagus198
heart11
intestine21
kidney28
liver4
lung32
lymph22
lymph node66
mammary gland13
mouth60
muscle56
ovary19
pharynx73
placenta3
prostate15
skin14
spleen168
stomach10
testis2
thymus87
trachea115
uterus56
vascular19
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor21
esophageal tumor231
gastrointestinal tumor8
germ cell tumor15
head and neck tumor29
leukemia63
liver tumor10
lung tumor19
lymphoma13
non-neoplasia51
ovarian tumor13
skin tumor15
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult31
embryoid body28
neonate64
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.2
adrenal gland8.3
appendix20.1
bone marrow11.9
cerebral cortex2
colon11.2
duodenum10.2
esophagus10.7
gallbladder13.5
heart muscle3.6
kidney14.1
liver5.2
lung13.7
lymph node23.1
ovary6.6
pancreas2.1
placenta10.1
prostate10.6
salivary gland6.2
skin5.7
small intestine12.5
spleen22.8
stomach9.6
testis4.6
thyroid gland8.8
urinary bladder17.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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