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> Protein (NX_O00746)
Protein (NX_O00746)
Protein
Gene SymbolNME4 to neXtProt (NX_O00746)
DescriptionNucleoside diphosphate kinase, mitochondrial
Chromosome16
Location16p13.3 (446725 ~ 460367) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.regulation of apoptotic process
  + 9 more...
.metal ion binding
.lipid binding
.ATP binding
.nucleoside diphosphate kinase activity
.cytosol
.mitochondrial matrix
.mitochondrial intermembrane space
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 0
2014-09-19protein level
2 23 0
2014-05-27protein level
2 23 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 12 0
2013-11-01protein level
1 12 0
2013-09-12protein level
1 12 0
2013-08-17protein level
1 12 0
2013-07-15protein level
1 10 0
2013-06-11protein level
1 10 0
2013-02-12protein level
1 8 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 10 1
2012-10-07protein level
1 10 1
2012-08-24protein level
1 9 1
2012-07-28protein level
1 9 1
2012-06-08protein level
1 9 1
2012-05-07protein level
1 9 1
2012-04-10protein level
1 9 1
2012-01-13protein level
1 6 1
2011-12-20protein level
1 6 1
2011-11-11protein level
1 6 1
2011-08-23protein level
1 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00746-1
5 7 0 20645.5396
NX_O00746-2
0 7 0 12970.3867
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744871,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
2 EBI-744871,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites100
blood16
bone83
bone marrow20
brain35
cervix20
connective tissue13
embryonic tissue75
esophagus49
eye62
heart78
intestine64
kidney28
larynx42
liver48
lung65
lymph node22
mammary gland178
mouth60
muscle28
nerve64
ovary108
pancreas56
pharynx73
placenta21
prostate353
salivary gland98
skin94
spleen18
stomach62
testis32
thyroid21
umbilical cord72
uterus64
vascular19
Health State
TissuesTPM*
normal52
adrenal tumor79
breast (mammary gland) tumor236
chondrosarcoma72
colorectal tumor35
esophageal tumor57
gastrointestinal tumor84
germ cell tumor34
glioma93
head and neck tumor82
kidney tumor58
leukemia21
liver tumor62
lung tumor136
ovarian tumor39
pancreatic tumor76
primitive neuroectodermal tumor of the CNS133
prostate cancer240
retinoblastoma107
skin tumor111
soft tissue/muscle tissue tumor79
uterine tumor44
Developmental Stage
TissuesTPM*
adult95
embryoid body71
blastocyst81
neonate32
fetus61
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75
adrenal gland69.6
appendix23.5
bone marrow73.3
cerebral cortex25.2
colon30.3
duodenum20.1
esophagus42.5
gallbladder43.6
heart muscle47.9
kidney28
liver48.6
lung26.1
lymph node20.2
ovary51.5
pancreas18.7
placenta29.2
prostate113
salivary gland59.9
skin15
small intestine19.8
spleen29.3
stomach25.6
testis33.7
thyroid gland38
urinary bladder63.6
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaLow
prostateMedium
rectumLow
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Low
skin 2Low
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601818, gene) Nonmetastatic cells 4, protein expressed in; NME4OMIM


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