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> Protein (NX_O00750)
Protein (NX_O00750)
Protein
Gene SymbolPIK3C2B to neXtProt (NX_O00750)
DescriptionPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Chromosome1
Location1q32.1 (204391756 ~ 204463852) to Ensembl
Sequene Features : Isoforms 1, Variants 219, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 219 11
2014-09-19protein level
1 164 11
2014-05-27protein level
1 164 11
2014-02-25protein level
1 159 11
2013-12-09protein level
1 110 11
2013-11-01protein level
1 110 10
2013-09-12protein level
1 110 10
2013-08-17protein level
1 110 10
2013-07-15protein level
1 75 1
2013-06-11protein level
1 75 1
2013-02-12protein level
1 52 1
2012-12-20protein level
1 51 1
2012-10-30protein level
1 67 1
2012-10-07protein level
1 67 1
2012-08-24protein level
1 52 1
2012-07-28protein level
1 52 1
2012-06-08protein level
1 60 1
2012-05-07protein level
1 60 1
2012-04-10protein level
1 60 1
2012-01-13protein level
1 44 1
2011-12-20protein level
1 44 1
2011-11-11protein level
1 44 1
2011-08-23protein level
1 44 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00750-1
78 0 0 184650.1296
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-641107,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-641107,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-641107,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-641107,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
5 EBI-641107,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone13
bone marrow20
brain31
cervix20
connective tissue6
embryonic tissue18
eye14
heart22
intestine56
kidney9
liver9
lung11
lymph node77
mammary gland13
mouth15
muscle18
ovary9
pancreas9
pharynx24
placenta63
prostate15
stomach31
testis4
thymus37
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor62
germ cell tumor22
glioma9
head and neck tumor14
kidney tumor14
liver tumor10
lung tumor9
lymphoma13
non-neoplasia10
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer9
Developmental Stage
TissuesTPM*
adult27
embryoid body28
blastocyst32
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.8
adrenal gland3
appendix14.3
bone marrow3.2
cerebral cortex8.7
colon16.4
duodenum12.5
esophagus9.9
gallbladder8.8
heart muscle7.7
kidney6.1
liver1.6
lung14.1
lymph node21.9
ovary1.8
pancreas2.3
placenta12.9
prostate5.3
salivary gland5.5
skin18.9
small intestine12.7
spleen14.6
stomach19
testis2.5
thyroid gland6.8
urinary bladder13.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602838, gene) Phosphatidylinositol 3-kinase, class 2, beta; PIK3C2BOMIM


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