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> Protein (NX_O00754)
Protein (NX_O00754)
Protein
Gene SymbolMAN2B1 to neXtProt (NX_O00754)
DescriptionLysosomal alpha-mannosidase
Chromosome19
Location19p13.2 (12757325 ~ 12777556) to Ensembl
Sequene Features : Isoforms 2, Variants 180, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein deglycosylation
.cellular protein modification process
.mannose metabolic process
.carbohydrate binding
.zinc ion binding
.alpha-mannosidase activity
.extracellular exosome
.lysosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 180 15
2014-09-19protein level
2 148 15
2014-05-27protein level
2 148 15
2014-02-25protein level
2 147 15
2013-12-09protein level
2 123 15
2013-11-01protein level
2 115 15
2013-09-12protein level
2 115 15
2013-08-17protein level
2 115 15
2013-07-15protein level
1 96 15
2013-06-11protein level
1 96 15
2013-02-12protein level
1 74 15
2012-12-20protein level
1 74 15
2012-10-30protein level
1 79 15
2012-10-07protein level
1 79 15
2012-08-24protein level
1 73 15
2012-07-28protein level
1 73 15
2012-06-08protein level
1 43 15
2012-05-07protein level
1 43 15
2012-04-10protein level
1 43 15
2012-01-13protein level
1 28 15
2011-12-20protein level
1 28 15
2011-11-11protein level
1 28 15
2011-08-23protein level
1 28 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O00754-1
1 48 0 113672.0447
NX_O00754-2
0 48 0 113543.9865
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
ascites50
bladder33
blood220
bone13
bone marrow328
brain178
cervix82
connective tissue858
embryonic tissue89
esophagus49
eye52
heart44
intestine112
kidney90
liver92
lung197
lymph90
lymph node111
mammary gland112
mouth755
muscle18
ovary206
pancreas74
pharynx24
placenta233
prostate110
skin132
spleen955
stomach177
testis303
thymus1417
thyroid21
tonsil470
trachea830
uterus94
vascular271
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma60
colorectal tumor97
esophageal tumor57
gastrointestinal tumor33
germ cell tumor18
glioma18
head and neck tumor14
kidney tumor14
leukemia10
liver tumor20
lung tumor29
lymphoma13
non-neoplasia1117
ovarian tumor144
pancreatic tumor76
primitive neuroectodermal tumor of the CNS39
prostate cancer19
retinoblastoma107
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult16
embryoid body42
blastocyst113
neonate32
fetus12
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.1
adrenal gland18
appendix64.2
bone marrow68.5
cerebral cortex9.4
colon33
duodenum28.9
esophagus22.5
gallbladder40.1
heart muscle13.3
kidney15.9
liver15.8
lung48
lymph node73.1
ovary15.2
pancreas23.2
placenta25.9
prostate21.6
salivary gland32.3
skin33.7
small intestine31.6
spleen81.9
stomach34.5
testis15.5
thyroid gland18.1
urinary bladder58.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2Medium
small intestineHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#248500, phenotype) Mannosidosis, alpha b, lysosomal; MANSAOMIM
2(*609458, gene) Mannosidase, alpha, class 2b, member 1; MAN2B1OMIM


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