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> Protein (NX_O14490)
Protein (NX_O14490)
Protein
Gene SymbolDLGAP1 to neXtProt (NX_O14490)
DescriptionDisks large-associated protein 1
Chromosome18
Location18p11.31 (3496030 ~ 4455335) to Ensembl
Sequene Features : Isoforms 7, Variants 140, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.synaptic transmission .N/A .neuronal postsynaptic density
.postsynaptic membrane
.cell junction
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 140 4
2014-09-19protein level
7 95 4
2014-05-27protein level
7 95 4
2014-02-25protein level
7 96 4
2013-12-09protein level
7 84 4
2013-11-01protein level
7 81 4
2013-09-12protein level
7 81 14
2013-08-17protein level
7 81 14
2013-07-15protein level
7 50 14
2013-06-11protein level
7 50 14
2013-02-12protein level
7 14 86
2012-12-20protein level
7 14 86
2012-10-30protein level
7 14 86
2012-10-07protein level
7 14 14
2012-08-24protein level
7 4 14
2012-07-28protein level
7 4 14
2012-06-08protein level
7 7 14
2012-05-07protein level
7 7 14
2012-04-10protein level
3 7 14
2012-01-13protein level
3 10 14
2011-12-20protein level
3 10 14
2011-11-11protein level
3 10 14
2011-08-23protein level
3 10 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14490-1
0 37 2 108804.8957
NX_O14490-2
0 23 1 75213.7299
NX_O14490-3
0 23 1 69924.6648
NX_O14490-4
2 21 1 76111.0521
NX_O14490-5
2 20 0 74011.0147
NX_O14490-6
2 22 1 76197.2921
NX_O14490-7
0 37 2 103515.8306
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1753207,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1753207,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-1753207,EBI-80389 DLG4  
  .regulation of grooming behavior
.positive regulation of excitatory postsynaptic membrane potential
.regulation of N-methyl-D-aspartate selective glutamate receptor activity
  + 22 more...
.scaffold protein binding
.neuroligin family protein binding
.ionotropic glutamate receptor binding
  + 10 more...
.neuronal postsynaptic density
.excitatory synapse
.postsynaptic membrane
  + 17 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain75
connective tissue20
embryonic tissue4
eye19
kidney14
lung5
muscle9
nerve64
ovary29
pancreas4
pituitary gland60
placenta7
prostate5
skin9
testis11
uterus4
Health State
TissuesTPM*
normal1
germ cell tumor3
glioma9
kidney tumor29
non-neoplasia20
ovarian tumor39
pancreatic tumor9
skin tumor15
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult2
embryoid body14
fetus25
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland6.9
cerebral cortex57.5
gallbladder8.2
ovary2.8
placenta1
prostate5.1
salivary gland2.8
spleen1.2
testis8.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605445, gene) Discs large-associated protein 1; DLGAP1OMIM


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