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> Protein (NX_O14492)
Protein (NX_O14492)
Protein
Gene SymbolSH2B2 to neXtProt (NX_O14492)
DescriptionSH2B adapter protein 2
Chromosome7
Location7q22.1 (101928405 ~ 101962178) to Ensembl
Sequene Features : Isoforms 1, Variants 0, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of JAK-STAT cascade
.intracellular signal transduction
.positive regulation of signal transduction
  + 3 more...
.JAK pathway signal transduction adaptor activity
.SH3/SH2 adaptor activity
.signal transducer activity
.plasma membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 0 1
2014-09-19protein level
1 0 1
2014-05-27protein level
1 0 1
2014-02-25protein level
1 0 1
2013-12-09protein level
1 0 1
2013-11-01protein level
1 0 1
2013-09-12protein level
1 0 1
2013-08-17protein level
1 0 1
2013-07-15protein level
1 0 1
2013-06-11protein level
1 0 1
2013-02-12protein level
1 0 1
2012-12-20protein level
1 0 1
2012-10-30protein level
1 0 1
2012-10-07protein level
1 0 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 1 1
2012-05-07protein level
1 1 1
2012-04-10protein level
1 1 1
2012-01-13protein level
1 1 1
2011-12-20protein level
1 1 1
2011-11-11protein level
1 1 1
2011-08-23protein level
1 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14492-1
26 0 1 67695.5265
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7507432,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain4
eye4
heart11
intestine12
kidney4
lung8
lymph225
lymph node155
mammary gland6
muscle56
ovary9
placenta7
prostate10
salivary gland49
spleen18
testis4
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor10
colorectal tumor8
germ cell tumor7
glioma27
head and neck tumor7
kidney tumor14
leukemia74
lymphoma138
ovarian tumor13
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor63
Developmental Stage
TissuesTPM*
adult3
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.6
appendix8
bone marrow3.7
cerebral cortex4.1
colon2.2
duodenum2.4
esophagus1.5
gallbladder2
kidney2.3
lung3
lymph node11.8
pancreas1.7
placenta3.4
prostate2.9
salivary gland2.4
skin2.5
small intestine2.4
spleen11.2
stomach3.6
testis3.6
thyroid gland2
urinary bladder3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605300, gene) Sh2b adaptor protein 2; SH2B2OMIM


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