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> Protein (NX_O14493)
Protein (NX_O14493)
Protein
Gene SymbolCLDN4 to neXtProt (NX_O14493)
DescriptionClaudin-4
Chromosome7
Location7q11.23 (73213872 ~ 73247014) to Ensembl
Sequene Features : Isoforms 1, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of skin barrier
.response to progesterone
.calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
  + 2 more...
.identical protein binding
.structural molecule activity
.transmembrane signaling receptor activity
.lateral plasma membrane
.apicolateral plasma membrane
.apical plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 34 1
2014-09-19protein level
1 16 1
2014-05-27protein level
1 16 1
2014-02-25protein level
1 16 1
2013-12-09protein level
1 11 1
2013-11-01protein level
1 11 1
2013-09-12protein level
1 11 1
2013-08-17protein level
1 11 1
2013-07-15protein level
1 11 1
2013-06-11protein level
1 11 1
2013-02-12protein level
1 5 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 5 1
2012-10-07protein level
1 5 1
2012-08-24protein level
1 5 1
2012-07-28protein level
1 5 1
2012-06-08protein level
1 6 1
2012-05-07protein level
1 6 1
2012-04-10protein level
1 6 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14493-1
8 0 1 22062.2941
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites1205
bladder301
bone13
bone marrow20
brain4
cervix288
connective tissue20
embryonic tissue136
esophagus1041
eye19
heart44
intestine719
kidney199
larynx85
liver9
lung167
lymph node55
mammary gland290
mouth15
nerve128
ovary512
pancreas238
parathyroid48
placenta476
prostate939
salivary gland148
skin9
spleen37
stomach1410
thymus12
thyroid128
trachea57
uterus202
Health State
TissuesTPM*
normal131
breast (mammary gland) tumor236
cervical tumor144
chondrosarcoma48
colorectal tumor346
esophageal tumor1043
gastrointestinal tumor1299
germ cell tumor49
head and neck tumor29
kidney tumor29
leukemia21
liver tumor20
lung tumor340
non-neoplasia41
ovarian tumor656
pancreatic tumor457
primitive neuroectodermal tumor of the CNS15
prostate cancer1271
skin tumor7
uterine tumor310
Developmental Stage
TissuesTPM*
adult287
embryoid body214
blastocyst32
fetus37
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
appendix17.3
colon173.5
duodenum80.6
esophagus95.5
gallbladder44.6
kidney37.3
liver3.1
lung46.8
pancreas26.6
placenta40.8
prostate73.5
salivary gland100.4
skin27.3
small intestine120.6
stomach9.5
thyroid gland61.2
urinary bladder76.5
Tissues
TissuesExpression level
appendixHigh
breastMedium
bronchusMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
kidneyLow
lungMedium
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
stomach 2Medium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602909, gene) Claudin 4; CLDN4OMIM


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