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> Protein (NX_O14503)
Protein (NX_O14503)
Protein
Gene SymbolBHLHE40 to neXtProt (NX_O14503)
DescriptionClass E basic helix-loop-helix protein 40
Chromosome3
Location3p26.1 (5020801 ~ 5027008) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 2
2014-09-19protein level
1 38 2
2014-05-27protein level
1 38 0
2014-02-25protein level
1 38 0
2013-12-09protein level
1 31 0
2013-11-01protein level
1 28 0
2013-09-12protein level
1 28 1
2013-08-17protein level
1 28 1
2013-07-15protein level
1 15 1
2013-06-11protein level
1 15 1
2013-02-12protein level
1 9 1
2012-12-20protein level
1 9 1
2012-10-30protein level
1 8 1
2012-10-07protein level
1 8 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 7 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14503-1
17 0 4 45481.106
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711810,EBI-10171734 KRTAP23-1  
  .N/A .N/A .intermediate filament
2 EBI-711810,EBI-5452954 SOX15  
  .positive regulation of myoblast proliferation
.positive regulation of G0 to G1 transition
.myoblast development
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
.cytoplasm
.nucleus
3 EBI-711810,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
4 EBI-711810,EBI-739806 CCNK  
  .positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
.negative regulation of cell cycle arrest
.cell division
  + 8 more...
.protein kinase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.cyclin-dependent protein serine/threonine kinase activity
.nucleus
.cyclin K-CDK13 complex
.cyclin K-CDK12 complex
5 EBI-711810,EBI-2367123 RHOBTB3  
  .retrograde transport, endosome to Golgi
.metabolic process
.small GTPase mediated signal transduction
.Rab GTPase binding
.ATPase activity
.GTP binding
.ATP binding
.extracellular exosome
.Golgi apparatus
6 EBI-711810,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
7 EBI-711810,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
8 EBI-711810,EBI-2622029 PDE6G  
  .positive regulation of G-protein coupled receptor protein signaling pathway
.positive regulation of epidermal growth factor receptor signaling pathway
.negative regulation of catalytic activity
  + 5 more...
.3',5'-cyclic-GMP phosphodiesterase activity
.cGMP binding
.enzyme inhibitor activity
.photoreceptor disc membrane
.plasma membrane
9 EBI-711810,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
10 EBI-711810,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
11 EBI-711810,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
12 EBI-711810,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
13 EBI-711810,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
14 EBI-711810,EBI-2562000 TOB2  
  .positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
15 EBI-711810,EBI-7451846 AANAT  
  .cellular response to cAMP
.response to calcium ion
.response to corticosterone
  + 12 more...
.arylamine N-acetyltransferase activity
.aralkylamine N-acetyltransferase activity
.perinuclear region of cytoplasm
.cytosol
16 EBI-711810,EBI-6447954 TTC23  
  .N/A .N/A .N/A
17 EBI-711810,EBI-2802782 CDPF1  
  .N/A .N/A .N/A
18 EBI-711810,EBI-10255841 LARP4  
  .regulation of cell morphogenesis
.cytoskeleton organization
.poly(A) RNA binding .membrane
19 EBI-711810,EBI-780319 RBM23  
  .mRNA processing .RNA binding
.nucleotide binding
.membrane
.nucleus
20 EBI-711810,EBI-8463848 SMYD1  
  .negative regulation of transcription, DNA-templated
.positive regulation of myoblast differentiation
.skeletal muscle cell differentiation
  + 4 more...
.metal ion binding
.histone-lysine N-methyltransferase activity
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleus
21 EBI-711810,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
22 EBI-711810,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
23 EBI-711810,EBI-373552 PLEKHB2  
  .N/A .N/A .recycling endosome membrane
24 EBI-711810,EBI-395927 NOC4L  
  .rRNA processing
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nuclear membrane
.Noc4p-Nop14p complex
  + 3 more...
25 EBI-711810,EBI-1052523 NAA50  
  .mitotic sister chromatid cohesion, centromeric
.histone H4 acetylation
.N-terminal protein amino acid acetylation
.peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
.H4 histone acetyltransferase activity
.peptide alpha-N-acetyltransferase activity
.extracellular exosome
.cytoplasm
26 EBI-711810,EBI-6285694 RHOJ  
  .retina vasculature morphogenesis in camera-type eye
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.cytosol
27 EBI-711810,EBI-10309345 TXNL4B  
  .mitotic nuclear division
.spliceosomal complex assembly
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
28 EBI-711810,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
ascites50
bladder502
blood179
bone41
bone marrow82
brain38
cervix123
connective tissue160
ear124
embryonic tissue70
esophagus49
eye129
heart33
intestine94
kidney118
larynx255
liver53
lung110
lymph node55
mammary gland152
mouth120
muscle56
nerve193
ovary68
pancreas140
pharynx122
pituitary gland60
placenta60
prostate73
skin94
spleen56
stomach62
testis27
thymus100
thyroid364
trachea135
uterus146
vascular19
Health State
TissuesTPM*
normal71
adrenal tumor79
bladder carcinoma682
breast (mammary gland) tumor161
cervical tumor115
chondrosarcoma96
colorectal tumor44
esophageal tumor57
gastrointestinal tumor109
germ cell tumor18
glioma55
head and neck tumor209
kidney tumor188
leukemia148
liver tumor72
lung tumor272
lymphoma27
non-neoplasia144
ovarian tumor65
pancreatic tumor104
primitive neuroectodermal tumor of the CNS7
prostate cancer57
skin tumor111
soft tissue/muscle tissue tumor31
uterine tumor266
Developmental Stage
TissuesTPM*
adult155
embryoid body185
blastocyst32
neonate32
fetus10
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue57.7
adrenal gland86.6
appendix53.2
bone marrow121.4
cerebral cortex33.9
colon32.5
duodenum27.6
esophagus199.9
gallbladder106.5
heart muscle44.1
kidney60.5
liver181
lung96.4
lymph node49.4
ovary46.5
pancreas37
placenta57.5
prostate67.8
salivary gland28.1
skin36.3
small intestine26.7
spleen22
stomach41.8
testis15
thyroid gland34.7
urinary bladder102.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604256, gene) Basic helix-loop-helix family, member e40; BHLHE40OMIM


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