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> Protein (NX_O14508)
Protein (NX_O14508)
Protein
Gene SymbolSOCS2 to neXtProt (NX_O14508)
DescriptionSuppressor of cytokine signaling 2
Chromosome12
Location12q22 (93963590 ~ 93977263) to Ensembl
Sequene Features : Isoforms 1, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.negative regulation of insulin receptor signaling pathway
  + 12 more...
.JAK pathway signal transduction adaptor activity
.insulin-like growth factor receptor binding
.growth hormone receptor binding
  + 2 more...
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 26 1
2014-09-19protein level
1 22 1
2014-05-27protein level
1 22 1
2014-02-25protein level
1 22 1
2013-12-09protein level
1 18 1
2013-11-01protein level
1 17 1
2013-09-12protein level
1 17 1
2013-08-17protein level
1 17 1
2013-07-15protein level
1 12 1
2013-06-11protein level
1 12 1
2013-02-12protein level
1 5 1
2012-12-20protein level
1 5 1
2012-10-30protein level
1 7 1
2012-10-07protein level
1 7 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 7 1
2012-04-10protein level
1 7 1
2012-01-13protein level
1 6 1
2011-12-20protein level
1 6 1
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14508-1
10 0 0 22158.2662
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-617737,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
2 EBI-617737,EBI-617321 EPOR  
  .decidualization
.erythropoietin-mediated signaling pathway
.heart development
  + 2 more...
.identical protein binding
.erythropoietin receptor activity
.integral component of plasma membrane
.extracellular region
3 EBI-617737,EBI-301231 TCEB1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of viral transcription
  + 7 more...
.N/A .elongin complex
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder33
blood49
bone41
bone marrow164
brain3
cervix20
connective tissue26
embryonic tissue14
eye4
heart11
intestine8
kidney9
liver14
lung8
lymph node22
mammary gland26
ovary19
pancreas4
parathyroid48
pharynx24
placenta24
prostate21
salivary gland49
skin4
stomach10
testis27
thymus37
umbilical cord72
uterus17
Health State
TissuesTPM*
normal9
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma36
gastrointestinal tumor16
germ cell tumor7
head and neck tumor7
kidney tumor14
leukemia74
liver tumor20
non-neoplasia41
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer96
retinoblastoma21
Developmental Stage
TissuesTPM*
adult11
embryoid body28
neonate32
fetus14
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.2
adrenal gland35.4
appendix10.3
bone marrow7.2
cerebral cortex4
colon16.3
duodenum11.5
esophagus15.8
gallbladder21.6
heart muscle15.7
kidney18.4
liver31.9
lung29.9
lymph node8.5
ovary6.9
pancreas5
placenta28.4
prostate58
salivary gland3.7
skin2.3
small intestine12.5
spleen6.3
stomach12
testis8.4
thyroid gland13
urinary bladder20
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605117, gene) Suppressor of cytokine signaling 2; SOCS2OMIM


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