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> Protein (NX_O14522)
Protein (NX_O14522)
Protein
Gene SymbolPTPRT to neXtProt (NX_O14522)
DescriptionReceptor-type tyrosine-protein phosphatase T
Chromosome20
Location20q12 (40701392 ~ 41818610) to Ensembl
Sequene Features : Isoforms 2, Variants 417, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.transmembrane receptor protein tyrosine kinase signaling pathway
.signal transduction
  + 3 more...
.delta-catenin binding
.cadherin binding
.gamma-catenin binding
  + 3 more...
.integral component of membrane
.cell surface
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 417 11
2014-09-19protein level
2 290 11
2014-05-27protein level
2 290 11
2014-02-25protein level
2 289 11
2013-12-09protein level
2 257 11
2013-11-01protein level
2 253 11
2013-09-12protein level
2 253 11
2013-08-17protein level
2 253 11
2013-07-15protein level
2 166 11
2013-06-11protein level
2 166 11
2013-02-12protein level
2 88 22
2012-12-20protein level
2 91 22
2012-10-30protein level
2 102 22
2012-10-07protein level
2 102 11
2012-08-24protein level
2 51 11
2012-07-28protein level
2 51 11
2012-06-08protein level
2 54 11
2012-05-07protein level
2 54 11
2012-04-10protein level
2 54 11
2012-01-13protein level
2 44 11
2011-12-20protein level
2 44 11
2011-11-11protein level
2 44 11
2011-08-23protein level
2 44 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14522-1
2 66 3 164241.062
NX_O14522-3
2 66 3 162030.9496
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-728180,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-728180,EBI-728153 PTPRN  
  .dense core granule maturation
.response to cAMP
.response to estrogen
  + 6 more...
.spectrin binding
.phosphatase activity
.integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain26
embryonic tissue4
eye33
mammary gland13
muscle65
pancreas4
placenta3
prostate10
testis11
thymus12
trachea19
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor21
germ cell tumor3
leukemia10
non-neoplasia20
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult9
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex13.3
placenta1.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608712, gene) Protein-tyrosine phosphatase, receptor-type, t; PTPRTOMIM


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