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> Protein (NX_O14526)
Protein (NX_O14526)
Protein
Gene SymbolFCHO1 to neXtProt (NX_O14526)
DescriptionFCH domain only protein 1
Chromosome19
Location19p13.11 (17858527 ~ 17899377) to Ensembl
Sequene Features : Isoforms 3, Variants 117, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.clathrin-mediated endocytosis
.clathrin coat assembly
.AP-2 adaptor complex binding .coated pit
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 117 2
2014-09-19protein level
3 85 2
2014-05-27protein level
3 85 2
2014-02-25protein level
3 85 2
2013-12-09protein level
3 68 2
2013-11-01protein level
3 66 2
2013-09-12protein level
3 66 4
2013-08-17protein level
3 66 4
2013-07-15protein level
2 42 4
2013-06-11protein level
2 42 4
2013-02-12protein level
2 27 6
2012-12-20protein level
2 25 6
2012-10-30protein level
2 28 6
2012-10-07protein level
2 28 3
2012-08-24protein level
2 27 3
2012-07-28protein level
2 27 3
2012-06-08protein level
2 0 3
2012-05-07protein level
2 0 3
2012-04-10protein level
2 0 3
2012-01-13protein level
2 0 3
2011-12-20protein level
2 0 3
2011-11-11protein level
2 0 3
2011-08-23protein level
2 0 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14526-1
0 33 0 96800.3804
NX_O14526-2
1 32 0 96568.3216
NX_O14526-3
0 30 0 90956.5493
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-719823,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
2 EBI-719823,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
3 EBI-719823,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood65
bone13
bone marrow143
brain53
cervix123
embryonic tissue28
eye23
intestine12
kidney9
lung5
lymph158
lymph node155
muscle37
ovary68
pancreas14
placenta3
skin9
spleen56
testis20
thymus138
uterus25
Health State
TissuesTPM*
normal26
colorectal tumor26
gastrointestinal tumor16
germ cell tumor22
glioma9
kidney tumor29
leukemia95
lung tumor19
lymphoma166
non-neoplasia10
ovarian tumor78
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor79
Developmental Stage
TissuesTPM*
adult19
embryoid body14
blastocyst48
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.4
adrenal gland2
appendix16.2
bone marrow11.1
cerebral cortex10.3
colon2.4
duodenum3.3
esophagus1
gallbladder3.7
liver1.3
lung3.8
lymph node22.7
ovary1.8
salivary gland1.4
skin11.9
small intestine2.5
spleen16.5
stomach4
testis4.5
urinary bladder5.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613437, gene) Fch domain only protein 1; FCHO1OMIM


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