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> Protein (NX_O14543)
Protein (NX_O14543)
Protein
Gene SymbolSOCS3 to neXtProt (NX_O14543)
DescriptionSuppressor of cytokine signaling 3
Chromosome17
Location17q25.3 (76352864 ~ 76356158) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.spongiotrophoblast differentiation
.trophoblast giant cell differentiation
.placenta blood vessel development
  + 16 more...
.protein kinase inhibitor activity .cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 0
2014-09-19protein level
1 16 0
2014-05-27protein level
1 16 0
2014-02-25protein level
1 16 0
2013-12-09protein level
1 14 0
2013-11-01protein level
1 14 0
2013-09-12protein level
1 14 0
2013-08-17protein level
1 14 0
2013-07-15protein level
1 10 0
2013-06-11protein level
1 10 0
2013-02-12protein level
1 6 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 6 0
2012-10-07protein level
1 6 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 20 0
2012-05-07protein level
1 20 0
2012-04-10protein level
1 20 0
2012-01-13protein level
1 19 0
2011-12-20protein level
1 19 0
2011-11-11protein level
1 19 0
2011-08-23protein level
1 19 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14543-1
11 0 0 24754.5556
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714146,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
2 EBI-714146,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-714146,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
4 EBI-714146,EBI-2133734 MAP1S  
  .neuron projection morphogenesis
.mitochondrion transport along microtubule
.regulation of chromatin disassembly
  + 5 more...
.actin filament binding
.beta-tubulin binding
.tubulin binding
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.neuronal cell body
  + 9 more...
5 EBI-714146,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
blood89
bone13
brain5
cervix20
connective tissue114
embryonic tissue23
eye76
heart22
intestine8
kidney4
larynx42
liver24
lung2
lymph node44
mammary gland52
mouth30
nerve64
ovary177
pancreas56
pharynx24
pituitary gland60
placenta35
prostate5
salivary gland49
skin4
stomach73
testis2
thymus37
thyroid21
trachea19
uterus34
vascular19
Health State
TissuesTPM*
normal31
bladder carcinoma56
breast (mammary gland) tumor10
chondrosarcoma120
gastrointestinal tumor50
germ cell tumor3
glioma27
head and neck tumor29
leukemia31
liver tumor31
lung tumor29
lymphoma27
non-neoplasia51
ovarian tumor157
pancreatic tumor9
soft tissue/muscle tissue tumor7
uterine tumor88
Developmental Stage
TissuesTPM*
adult48
embryoid body42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue184.9
adrenal gland43.4
appendix81.5
bone marrow71
cerebral cortex9.1
colon32.1
duodenum15.7
esophagus64.9
gallbladder186.6
heart muscle17.4
kidney17.7
liver44.5
lung93.3
lymph node41.8
ovary13.2
pancreas21
placenta46.8
prostate63.3
salivary gland18.7
skin2.4
small intestine21.2
spleen12.6
stomach15.7
testis8.9
thyroid gland22.9
urinary bladder126.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604176, gene) Suppressor of cytokine signaling 3; SOCS3OMIM


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