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> Protein (NX_O14544)
Protein (NX_O14544)
Protein
Gene SymbolSOCS6 to neXtProt (NX_O14544)
DescriptionSuppressor of cytokine signaling 6
Chromosome18
Location18q22.2 (67956137 ~ 67997436) to Ensembl
Sequene Features : Isoforms 1, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of T cell activation
.negative regulation of JAK-STAT cascade
.regulation of growth
  + 6 more...
.protein kinase inhibitor activity .cytoplasm
.immunological synapse
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 68 2
2014-09-19protein level
1 52 2
2014-05-27protein level
1 52 2
2014-02-25protein level
1 52 2
2013-12-09protein level
1 43 2
2013-11-01protein level
1 43 2
2013-09-12protein level
1 43 2
2013-08-17protein level
1 43 2
2013-07-15protein level
1 28 2
2013-06-11protein level
1 28 2
2013-02-12protein level
1 11 1
2012-12-20protein level
1 10 1
2012-10-30protein level
1 13 1
2012-10-07protein level
1 13 1
2012-08-24protein level
1 11 1
2012-07-28protein level
1 11 1
2012-06-08protein level
1 8 1
2012-05-07protein level
1 8 1
2012-04-10protein level
1 8 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14544-1
21 0 0 59490.4621
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3929549,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-3929549,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
3 EBI-3929549,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-3929549,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
5 EBI-3929549,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood32
bone13
brain27
connective tissue20
embryonic tissue37
eye28
heart11
intestine8
kidney42
liver29
lung20
mammary gland39
mouth15
muscle37
pancreas9
parathyroid97
placenta45
prostate5
salivary gland98
skin47
testis6
thyroid42
trachea19
uterus47
vascular19
Health State
TissuesTPM*
normal25
bladder carcinoma56
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor8
germ cell tumor15
glioma18
head and neck tumor37
kidney tumor29
leukemia21
liver tumor41
lung tumor19
non-neoplasia62
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult27
embryoid body14
blastocyst65
neonate64
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland8.6
appendix6.5
bone marrow8.3
cerebral cortex11
colon17
duodenum14.2
esophagus15.6
gallbladder14.9
heart muscle8.7
kidney9.6
liver17.2
lung9.1
lymph node3.4
ovary10.8
pancreas6.4
placenta17
prostate8.6
salivary gland8.4
skin6
small intestine21.2
spleen4.1
stomach12.5
testis7.1
thyroid gland12.4
urinary bladder9.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605118, gene) Suppressor of cytokine signaling 4; SOCS4OMIM


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