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> Protein (NX_O14545)
Protein (NX_O14545)
Protein
Gene SymbolTRAFD1 to neXtProt (NX_O14545)
DescriptionTRAF-type zinc finger domain-containing protein 1
Chromosome12
Location12q24.13 (112563305 ~ 112591407) to Ensembl
Sequene Features : Isoforms 2, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of innate immune response
.response to cytokine
.metal ion binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 73 9
2014-09-19protein level
1 56 9
2014-05-27protein level
1 56 9
2014-02-25protein level
1 56 9
2013-12-09protein level
1 46 9
2013-11-01protein level
1 44 8
2013-09-12protein level
1 44 7
2013-08-17protein level
1 44 7
2013-07-15protein level
1 27 6
2013-06-11protein level
1 27 6
2013-02-12protein level
1 17 7
2012-12-20protein level
1 18 7
2012-10-30protein level
1 21 7
2012-10-07protein level
1 21 7
2012-08-24protein level
1 20 7
2012-07-28protein level
1 20 7
2012-06-08protein level
1 21 7
2012-05-07protein level
1 18 7
2012-04-10protein level
1 18 7
2012-01-13protein level
1 12 7
2011-12-20protein level
1 12 7
2011-11-11protein level
1 12 6
2011-08-23protein level
1 12 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14545-1
18 8 0 64799.9618
NX_O14545-2
2 8 0 19021.3312
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1396921,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-1396921,EBI-6165879 NGLY1  
  .glycoprotein catabolic process .metal ion binding
.peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder133
blood155
bone27
bone marrow41
brain75
cervix103
connective tissue67
embryonic tissue46
esophagus99
eye57
heart44
intestine60
kidney61
liver58
lung68
lymph112
lymph node167
mammary gland72
mouth90
muscle37
nerve64
ovary187
pancreas42
pharynx220
placenta24
prostate79
salivary gland296
skin128
spleen243
stomach41
testis144
thymus62
thyroid85
tonsil411
trachea57
umbilical cord72
uterus81
vascular19
Health State
TissuesTPM*
normal75
breast (mammary gland) tumor96
cervical tumor115
chondrosarcoma72
colorectal tumor53
esophageal tumor57
gastrointestinal tumor33
germ cell tumor178
glioma65
head and neck tumor89
kidney tumor87
leukemia95
liver tumor93
lung tumor48
lymphoma110
non-neoplasia31
ovarian tumor183
pancreatic tumor85
primitive neuroectodermal tumor of the CNS70
prostate cancer86
retinoblastoma21
skin tumor143
soft tissue/muscle tissue tumor87
uterine tumor99
Developmental Stage
TissuesTPM*
adult57
embryoid body28
blastocyst32
neonate64
fetus53
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland11.5
appendix32.6
bone marrow18.2
cerebral cortex14.8
colon17.7
duodenum15.1
esophagus22.5
gallbladder20.6
heart muscle18
kidney12.7
liver6.9
lung21.7
lymph node37.1
ovary18.9
pancreas5.1
placenta19
prostate19.3
salivary gland12.1
skin30.5
small intestine17.9
spleen28.6
stomach17.5
testis33.1
thyroid gland15.4
urinary bladder32.1
Tissues
TissuesExpression level
adrenal glandLow
breastLow
cerebral cortexLow
endometrium 2Low
esophagusLow
fallopian tubeLow
gallbladderLow
hippocampusLow
lateral ventricleLow
lymph nodeMedium
oral mucosaLow
skeletal muscleLow
skin 1Low
small intestineLow
testisHigh
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613197, gene) Traf-type zinc finger domain-containing 1; TRAFD1OMIM


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