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> Protein (NX_O14559)
Protein (NX_O14559)
Protein
Gene SymbolARHGAP33 to neXtProt (NX_O14559)
DescriptionRho GTPase-activating protein 33
Chromosome19
Location19q13.12 (36265434 ~ 36279724) to Ensembl
Sequene Features : Isoforms 4, Variants 154, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of small GTPase mediated signal transduction
.protein transport
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 154 3
2014-09-19protein level
4 105 3
2014-05-27protein level
4 105 3
2014-02-25protein level
4 104 3
2013-12-09protein level
4 78 3
2013-11-01protein level
4 75 3
2013-09-12protein level
4 75 3
2013-08-17protein level
4 76 3
2013-07-15protein level
4 45 3
2013-06-11protein level
4 45 3
2013-02-12protein level
4 21 8
2012-12-20protein level
4 23 8
2012-10-30protein level
4 26 8
2012-10-07protein level
4 26 3
2012-08-24protein level
4 25 3
2012-07-28protein level
4 25 3
2012-06-08protein level
4 29 3
2012-05-07protein level
4 21 3
2012-04-10protein level
4 21 3
2012-01-13protein level
4 14 3
2011-12-20protein level
4 14 3
2011-11-11protein level
4 14 3
2011-08-23protein level
4 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14559-1
0 54 2 137127.2379
NX_O14559-10
2 46 2 119704.6426
NX_O14559-11
1 47 2 120989.4283
NX_O14559-12
6 5 0 26841.2048
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1210010,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
brain39
cervix20
embryonic tissue18
eye14
intestine8
kidney14
lung5
lymph node66
muscle9
ovary29
pancreas9
prostate21
testis22
thymus25
uterus4
Health State
TissuesTPM*
normal19
bladder carcinoma56
colorectal tumor8
germ cell tumor11
glioma55
kidney tumor14
leukemia31
non-neoplasia20
ovarian tumor39
pancreatic tumor19
prostate cancer28
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
blastocyst65
fetus35
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.3
adrenal gland9.8
appendix7.8
bone marrow20.3
cerebral cortex20.9
colon3.6
duodenum9.8
esophagus3.4
gallbladder5.1
heart muscle3.6
kidney5.2
liver1.6
lung6.7
lymph node12.5
ovary14.4
pancreas2.6
placenta3.4
prostate9
salivary gland9.1
skin12.8
small intestine4.9
spleen11.3
stomach7.1
testis25.2
thyroid gland7.6
urinary bladder4.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614902, gene) Rho gtpase-activating protein 33; ARHGAP33OMIM


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