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> Protein (NX_O14653)
Protein (NX_O14653)
Protein
Gene SymbolGOSR2 to neXtProt (NX_O14653)
DescriptionGolgi SNAP receptor complex member 2
Chromosome17
Location17q21.32 (45000483 ~ 45105003) to Ensembl
Sequene Features : Isoforms 3, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane fusion
.vesicle fusion with Golgi apparatus
.cellular protein metabolic process
  + 7 more...
.SNAP receptor activity
.transporter activity
.SNARE binding
.late endosome membrane
.SNARE complex
.integral component of membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 29 1
2014-09-19protein level
3 26 1
2014-05-27protein level
3 26 1
2014-02-25protein level
3 26 1
2013-12-09protein level
3 21 1
2013-11-01protein level
3 21 1
2013-09-12protein level
3 21 1
2013-08-17protein level
3 21 1
2013-07-15protein level
3 17 1
2013-06-11protein level
3 17 1
2013-02-12protein level
3 12 3
2012-12-20protein level
3 12 3
2012-10-30protein level
3 13 3
2012-10-07protein level
3 13 1
2012-08-24protein level
3 13 1
2012-07-28protein level
3 13 1
2012-06-08protein level
3 16 1
2012-05-07protein level
3 14 1
2012-04-10protein level
2 13 1
2012-01-13protein level
2 8 1
2011-12-20protein level
2 8 1
2011-11-11protein level
2 8 1
2011-08-23protein level
2 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14653-1
1 7 0 24759.693
NX_O14653-2
1 7 0 24568.4245
NX_O14653-3
2 6 0 22710.5326
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4401517,EBI-2695795 STX6  
  .Golgi ribbon formation
.Golgi vesicle transport
.retrograde transport, endosome to Golgi
  + 4 more...
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.trans-Golgi network membrane
.SNARE complex
  + 6 more...
2 EBI-4401517,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
3 EBI-4401517,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
4 EBI-4401517,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
5 EBI-4401517,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood32
bone55
bone marrow123
brain27
connective tissue26
embryonic tissue75
eye95
heart44
intestine43
kidney61
liver34
lung71
lymph node77
mammary gland66
mouth45
ovary39
pancreas60
parathyroid97
pharynx73
pituitary gland121
placenta42
prostate63
salivary gland49
skin71
spleen18
stomach94
testis48
thymus25
umbilical cord72
uterus34
vascular38
Health State
TissuesTPM*
normal53
breast (mammary gland) tumor42
chondrosarcoma60
colorectal tumor71
gastrointestinal tumor84
germ cell tumor56
glioma83
head and neck tumor44
kidney tumor29
liver tumor41
lung tumor58
lymphoma96
non-neoplasia20
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS78
prostate cancer19
retinoblastoma43
skin tumor87
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult55
embryoid body157
blastocyst48
neonate32
fetus50
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.6
adrenal gland34
appendix33.9
bone marrow15.9
cerebral cortex35.5
colon34
duodenum67
esophagus34.4
gallbladder33.5
heart muscle42.8
kidney54.3
liver24.1
lung29.2
lymph node41.2
ovary39.4
pancreas22.3
placenta42
prostate32.9
salivary gland38.5
skin25.1
small intestine58.2
spleen41.9
stomach34
testis60.3
thyroid gland47.8
urinary bladder42
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604027, gene) Golgi snap receptor complex member 2; GOSR2OMIM
2(#614018, phenotype) Epilepsy, progressive myoclonic 6; EPM6OMIM


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