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> Protein (NX_O14730)
Protein (NX_O14730)
Protein
Gene SymbolRIOK3 to neXtProt (NX_O14730)
DescriptionSerine/threonine-protein kinase RIO3
Chromosome18
Location18q11.2 (21032787 ~ 21066567) to Ensembl
Sequene Features : Isoforms 2, Variants 63, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chromosome segregation .ATP binding
.protein serine/threonine kinase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 63 12
2014-09-19protein level
2 43 12
2014-05-27protein level
2 43 12
2014-02-25protein level
2 43 12
2013-12-09protein level
2 32 12
2013-11-01protein level
2 31 6
2013-09-12protein level
2 31 5
2013-08-17protein level
2 31 5
2013-07-15protein level
2 20 4
2013-06-11protein level
2 20 4
2013-02-12protein level
2 10 6
2012-12-20protein level
2 10 6
2012-10-30protein level
2 12 6
2012-10-07protein level
2 12 3
2012-08-24protein level
2 12 3
2012-07-28protein level
2 12 3
2012-06-08protein level
2 13 3
2012-05-07protein level
2 11 3
2012-04-10protein level
2 11 3
2012-01-13protein level
2 11 3
2011-12-20protein level
2 11 3
2011-11-11protein level
2 11 3
2011-08-23protein level
2 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14730-1
1 21 0 59055.1483
NX_O14730-2
0 21 0 58632.9539
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047061,EBI-495095 CASP10  
  .apoptotic signaling pathway
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 3 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.ubiquitin protein ligase binding
.cysteine-type endopeptidase activity
.ripoptosome
.CD95 death-inducing signaling complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder100
blood32
bone55
bone marrow41
brain50
cervix82
connective tissue67
embryonic tissue75
esophagus49
eye43
heart55
intestine25
kidney37
liver48
lung29
lymph67
lymph node155
mammary gland13
mouth347
muscle37
ovary29
pancreas23
parathyroid97
pharynx49
pituitary gland60
placenta77
prostate26
salivary gland148
skin33
spleen74
stomach52
testis135
thymus175
thyroid85
trachea231
umbilical cord72
uterus12
Health State
TissuesTPM*
normal69
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma12
colorectal tumor17
esophageal tumor57
gastrointestinal tumor50
germ cell tumor68
glioma27
head and neck tumor194
kidney tumor14
leukemia10
liver tumor41
lung tumor19
lymphoma69
non-neoplasia93
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer28
retinoblastoma86
uterine tumor22
Developmental Stage
TissuesTPM*
adult43
embryoid body85
blastocyst97
neonate128
fetus75
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.7
adrenal gland26.7
appendix35.3
bone marrow189.9
cerebral cortex21.3
colon64.9
duodenum69.9
esophagus88.5
gallbladder40.7
heart muscle29.2
kidney32.5
liver38.6
lung33.7
lymph node38.2
ovary23.7
pancreas19.1
placenta47.8
prostate31.4
salivary gland25.3
skin53.5
small intestine91.5
spleen33.6
stomach55.2
testis40.5
thyroid gland32.4
urinary bladder35.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603579, gene) Sudd, aspergillus nidulans, homolog of; SUDDOMIM


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