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> Protein (NX_O14733)
Protein (NX_O14733)
Protein
Gene SymbolMAP2K7 to neXtProt (NX_O14733)
DescriptionDual specificity mitogen-activated protein kinase kinase 7
Chromosome19
Location19p13.2 (7968728 ~ 7979363) to Ensembl
Sequene Features : Isoforms 4, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 61 8
2014-09-19protein level
4 39 8
2014-05-27protein level
4 39 8
2014-02-25protein level
4 39 8
2013-12-09protein level
4 36 8
2013-11-01protein level
4 34 8
2013-09-12protein level
4 34 8
2013-08-17protein level
4 34 8
2013-07-15protein level
4 20 6
2013-06-11protein level
4 20 6
2013-02-12protein level
4 9 24
2012-12-20protein level
4 9 24
2012-10-30protein level
4 9 24
2012-10-07protein level
4 9 6
2012-08-24protein level
4 9 6
2012-07-28protein level
4 9 6
2012-06-08protein level
4 12 6
2012-05-07protein level
4 12 6
2012-04-10protein level
4 12 6
2012-01-13protein level
4 12 6
2011-12-20protein level
4 12 6
2011-11-11protein level
4 12 3
2011-08-23protein level
4 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14733-1
0 21 0 47454.3684
NX_O14733-2
4 20 0 51847.541
NX_O14733-3
2 20 0 49039.2987
NX_O14733-4
1 20 0 48150.6567
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-492605,EBI-4567563 CFLAR  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.enzyme activator activity
.protease binding
.ripoptosome
.membrane raft
.CD95 death-inducing signaling complex
  + 3 more...
2 EBI-492605,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
3 EBI-492605,EBI-448187 GADD45B  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
4 EBI-492605,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
5 EBI-492605,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
6 EBI-492605,EBI-78404 MAPK8IP1  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone marrow20
brain15
cervix20
embryonic tissue32
eye81
heart11
intestine73
kidney42
liver4
lung20
lymph node189
mammary gland13
muscle28
ovary108
pancreas37
placenta24
prostate26
skin23
testis75
thymus25
tonsil58
uterus21
vascular19
Health State
TissuesTPM*
normal27
adrenal tumor79
breast (mammary gland) tumor21
colorectal tumor26
gastrointestinal tumor8
germ cell tumor22
glioma83
kidney tumor14
leukemia84
lymphoma27
non-neoplasia10
ovarian tumor105
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult20
embryoid body28
blastocyst32
fetus32
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.2
adrenal gland9.7
appendix15.4
bone marrow18.5
cerebral cortex9.3
colon9.6
duodenum13.4
esophagus7.4
gallbladder9.4
heart muscle9.6
kidney11.3
liver5.8
lung11.5
lymph node13.4
ovary14.5
pancreas9
placenta11.9
prostate13
salivary gland12.7
skin16.2
small intestine12.1
spleen18.3
stomach12.2
testis15.8
thyroid gland10
urinary bladder9.8
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderLow
heart muscleMedium
hippocampusMedium
kidneyLow
liverLow
lungHigh
lymph nodeMedium
nasopharynxLow
ovaryLow
pancreasMedium
parathyroid glandLow
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603014, gene) Mitogen-activated protein kinase kinase 7; MAP2K7OMIM


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