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> Protein (NX_O14777)
Protein (NX_O14777)
Protein
Gene SymbolNDC80 to neXtProt (NX_O14777)
DescriptionKinetochore protein NDC80 homolog
Chromosome18
Location18p11.32 (2571510 ~ 2616634) to Ensembl
Sequene Features : Isoforms 1, Variants 64, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 64 11
2014-09-19protein level
1 49 11
2014-05-27protein level
1 49 11
2014-02-25protein level
1 48 11
2013-12-09protein level
1 42 11
2013-11-01protein level
1 39 9
2013-09-12protein level
1 39 9
2013-08-17protein level
1 39 9
2013-07-15protein level
1 21 5
2013-06-11protein level
1 21 5
2013-02-12protein level
1 8 9
2012-12-20protein level
1 7 9
2012-10-30protein level
1 9 9
2012-10-07protein level
1 9 9
2012-08-24protein level
1 8 9
2012-07-28protein level
1 8 9
2012-06-08protein level
1 11 9
2012-05-07protein level
1 9 9
2012-04-10protein level
1 9 9
2012-01-13protein level
1 9 9
2011-12-20protein level
1 9 9
2011-11-11protein level
1 9 9
2011-08-23protein level
1 9 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14777-1
37 0 0 73866.3053
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715849,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-715849,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-715849,EBI-739806 CCNK  
  .positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
.negative regulation of cell cycle arrest
.cell division
  + 8 more...
.protein kinase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.cyclin-dependent protein serine/threonine kinase activity
.nucleus
.cyclin K-CDK13 complex
.cyclin K-CDK12 complex
4 EBI-715849,EBI-1001132 ZWINT  
  .establishment of localization in cell
.cell division
.small GTPase mediated signal transduction
  + 3 more...
.protein N-terminus binding .dendrite
.cytosol
.cytoplasm
  + 3 more...
5 EBI-715849,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
6 EBI-715849,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
7 EBI-715849,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
8 EBI-715849,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
9 EBI-715849,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
10 EBI-715849,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
11 EBI-715849,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
12 EBI-715849,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
13 EBI-715849,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
14 EBI-715849,EBI-10181525 RUFY4  
  .N/A .metal ion binding .N/A
15 EBI-715849,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
16 EBI-715849,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
17 EBI-715849,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
18 EBI-715849,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
19 EBI-715849,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
20 EBI-715849,EBI-724102 NUF2  
  .cell division
.small GTPase mediated signal transduction
.mitotic nuclear division
  + 2 more...
.N/A .Ndc80 complex
.membrane
.cytosol
  + 3 more...
21 EBI-715849,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
22 EBI-715849,EBI-1003700 CENPH  
  .kinetochore organization
.kinetochore assembly
.CENP-A containing nucleosome assembly
  + 3 more...
.kinetochore binding .cytosol
.nucleoplasm
.nucleus
  + 2 more...
23 EBI-715849,EBI-999909 SPC25  
  .cell division
.small GTPase mediated signal transduction
.mitotic nuclear division
  + 3 more...
.N/A .Ndc80 complex
.cytosol
.nucleus
.condensed chromosome kinetochore
24 EBI-715849,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
25 EBI-715849,EBI-749920 CALCOCO1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.armadillo repeat domain binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
.nuclear chromatin
26 EBI-715849,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
27 EBI-715849,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder200
blood40
bone41
bone marrow82
brain22
cervix144
connective tissue33
embryonic tissue70
heart67
intestine21
kidney9
liver53
lung8
lymph22
lymph node11
mammary gland59
mouth15
muscle28
ovary9
pancreas9
pharynx49
placenta21
prostate21
skin47
stomach10
testis29
thymus138
thyroid21
uterus34
vascular19
Health State
TissuesTPM*
normal20
bladder carcinoma227
breast (mammary gland) tumor42
cervical tumor202
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor25
germ cell tumor64
glioma74
head and neck tumor29
kidney tumor14
leukemia74
liver tumor41
lymphoma41
non-neoplasia20
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS110
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
embryoid body100
blastocyst32
neonate160
fetus30
infant127
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix9.3
bone marrow16.3
colon6.3
duodenum4.8
esophagus4
gallbladder2.5
lymph node17
placenta8
prostate4.7
skin4.4
small intestine5.5
spleen4.5
stomach3.2
testis13.1
urinary bladder5.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*607272, gene) Ndc80, s. cerevisiae, homolog of; NDC80OMIM


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