Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O14787)
Protein (NX_O14787)
Protein
Gene SymbolTNPO2 to neXtProt (NX_O14787)
DescriptionTransportin-2
Chromosome19
Location19p13.2 (12810008 ~ 12834825) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular protein transport .nuclear localization sequence binding .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 2
2014-09-19protein level
2 44 2
2014-05-27protein level
2 44 6
2014-02-25protein level
2 44 6
2013-12-09protein level
2 41 6
2013-11-01protein level
2 41 4
2013-09-12protein level
2 41 4
2013-08-17protein level
2 41 4
2013-07-15protein level
2 27 3
2013-06-11protein level
2 27 3
2013-02-12protein level
2 7 6
2012-12-20protein level
2 7 6
2012-10-30protein level
2 7 6
2012-10-07protein level
2 7 3
2012-08-24protein level
2 2 3
2012-07-28protein level
2 2 3
2012-06-08protein level
2 19 3
2012-05-07protein level
2 19 3
2012-04-10protein level
2 19 3
2012-01-13protein level
2 21 3
2011-12-20protein level
2 21 3
2011-11-11protein level
2 21 3
2011-08-23protein level
2 21 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14787-1
2 31 5 101321.9457
NX_O14787-2
0 31 6 100342.4036
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-431907,EBI-746999 KLHL2  
  .protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
2 EBI-431907,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
3 EBI-431907,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
4 EBI-431907,EBI-946029 C1orf94  
  .N/A .N/A .N/A
5 EBI-431907,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
6 EBI-431907,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood32
bone27
bone marrow82
brain18
connective tissue6
ear62
embryonic tissue18
eye23
heart22
intestine30
kidney23
larynx42
lung50
lymph node33
mammary gland13
muscle9
ovary39
pancreas74
pharynx24
placenta3
prostate63
skin14
spleen18
stomach10
testis43
umbilical cord290
uterus17
Health State
TissuesTPM*
normal63
adrenal tumor79
breast (mammary gland) tumor96
chondrosarcoma60
colorectal tumor71
esophageal tumor115
gastrointestinal tumor67
germ cell tumor102
glioma93
head and neck tumor52
kidney tumor58
leukemia63
liver tumor20
lung tumor38
lymphoma41
non-neoplasia20
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS39
prostate cancer28
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult53
embryoid body114
blastocyst97
neonate32
fetus96
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.9
adrenal gland25.2
appendix23.6
bone marrow18.8
cerebral cortex47.5
colon16.7
duodenum17
esophagus28.7
gallbladder24.3
heart muscle23.7
kidney21.4
liver7.7
lung23.2
lymph node24.7
ovary42.7
pancreas14.1
placenta22.7
prostate24.1
salivary gland16.8
skin47.8
small intestine16.3
spleen24.6
stomach17.1
testis46.2
thyroid gland29.6
urinary bladder25.9
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderLow
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
nasopharynxMedium
oral mucosaLow
pancreasLow
placentaMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603002, gene) Transportin 2; TNPO2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center