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> Protein (NX_O14796)
Protein (NX_O14796)
Protein
Gene SymbolSH2D1B to neXtProt (NX_O14796)
DescriptionSH2 domain-containing protein 1B
Chromosome1
Location1q23.3 (162365056 ~ 162381928) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 0
2014-09-19protein level
2 18 0
2014-05-27protein level
2 18 0
2014-02-25protein level
2 19 0
2013-12-09protein level
2 15 0
2013-11-01protein level
2 15 0
2013-09-12protein level
2 15 0
2013-08-17protein level
2 15 0
2013-07-15protein level
2 9 0
2013-06-11protein level
2 9 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 4 0
2012-04-10protein level
2 4 0
2012-01-13protein level
2 2 0
2011-12-20protein level
2 2 0
2011-11-11protein level
2 2 0
2011-08-23protein level
2 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14796-1
3 4 0 15286.9716
NX_O14796-2
1 4 0 9018.4823
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3923013,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-3923013,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
3 EBI-3923013,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-3923013,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
5 EBI-3923013,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
6 EBI-3923013,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
7 EBI-3923013,EBI-6691679 CD84  
  .leukocyte migration
.blood coagulation
.homophilic cell adhesion via plasma membrane adhesion molecules
.defense response
.receptor activity .extracellular exosome
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood65
kidney4
lung2
muscle9
pharynx49
skin4
spleen74
stomach10
Health State
TissuesTPM*
normal4
gastrointestinal tumor8
skin tumor7
Developmental Stage
TissuesTPM*
adult2
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
bone marrow3.5
esophagus1.5
lung2.9
lymph node1.4
small intestine1.1
spleen7.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608510, gene) Sh2 domain-containing 1b; SH2D1BOMIM


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